ProBDNF and its receptors in immune-mediated inflammatory diseases: Novel insights into the regulation of metabolism and mitochondria

Q Li, YZ Hu, S Gao, PF Wang, ZL Hu… - Frontiers in …, 2023 - frontiersin.org
Immune-mediated inflammatory diseases (IMIDs) consist of a common and clinically diverse
group of diseases. Despite remarkable progress in the past two decades, no remission is …

Cellular response to β‐amyloid neurotoxicity in Alzheimer's disease and implications in new therapeutics

H Zhang, X Li, X Wang, J Xu, F Elefant… - Animal models and …, 2023 - Wiley Online Library
Abstract β‐Amyloid (Aβ) is a specific pathological hallmark of Alzheimer's disease (AD).
Because of its neurotoxicity, AD patients exhibit multiple brain dysfunctions. Disease …

Resveratrol induces autophagy and apoptosis in non-small-cell lung cancer cells by activating the NGFR-AMPK-mTOR pathway

J Li, Y Fan, Y Zhang, Y Liu, Y Yu, M Ma - Nutrients, 2022 - mdpi.com
Resveratrol (RSV) has been reported to induce autophagy and apoptosis in non-small-cell
lung cancer A549 cells, and the nerve growth factor receptor (NGFR) regulates autophagy …

NGFR Gene and Single Nucleotide Polymorphisms, rs2072446 and rs11466162, Playing Roles in Psychiatric Disorders

L Zhao, B Hou, L Ji, D Ren, F Yuan, L Liu, Y Bi, F Yang… - Brain Sciences, 2022 - mdpi.com
Psychiatric disorders are a class of complex disorders characterized by brain dysfunction
with varying degrees of impairment in cognition, emotion, consciousness and behavior …

P75 neurotrophin receptor as a therapeutic target for drug development to treat neurological diseases

LL Xiong, L Chen, IB Deng, XF Zhou… - European Journal of …, 2022 - Wiley Online Library
The interaction of neurotrophins with their receptors is involved in the pathogenesis and
progression of various neurological diseases, including Alzheimer's disease, Parkinson's …

The p75 neurotrophin receptor attenuates secondary thalamic damage after cortical infarction by promoting angiogenesis

L Peng, K Li, D Li, X Zuo, L Zhan… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Angiogenesis is crucial in neuroprotection of secondary thalamic injury after
cortical infarction. The p75 neurotrophin receptor (p75NTR) plays a key role in activating …

P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke

SS Deshpande, SC Malik, P Conforti, J Lin… - Cell and Tissue …, 2022 - Springer
Stroke is the leading cause of adult disability. Endogenous neural stem/progenitor cells
(NSPCs) originating from the subventricular zone (SVZ) contribute to the brain repair …

Human NGF “Painless” Ocular Delivery for Retinitis Pigmentosa: An In Vivo Study

D Napoli, N Orsini, G Salamone, MA Calvello… - Eneuro, 2024 - eneuro.org
Retinitis pigmentosa (RP) is a family of genetically heterogeneous diseases still without a
cure. Despite the causative genetic mutation typically not expressed in cone photoreceptors …

RELA is required for CD271 expression and stem-like characteristics in hypopharyngeal cancer

A Nakazato, M Mochizuki, R Shibuya-Takahashi… - Scientific Reports, 2022 - nature.com
CD271 (also referred to as nerve growth factor receptor or p75NTR) is expressed on cancer
stem cells in hypopharyngeal cancer (HPC) and regulates cell proliferation. Because …

Fading memories in aging and neurodegeneration: Is p75 neurotrophin receptor a culprit?

LW Wong, Z Wang, SRX Ang, S Sajikumar - Ageing Research Reviews, 2022 - Elsevier
Aging and age-related neurodegenerative diseases have become one of the major
concerns in modern times as cognitive abilities tend to decline when we get older. It is well …