ProBDNF and its receptors in immune-mediated inflammatory diseases: Novel insights into the regulation of metabolism and mitochondria
Immune-mediated inflammatory diseases (IMIDs) consist of a common and clinically diverse
group of diseases. Despite remarkable progress in the past two decades, no remission is …
group of diseases. Despite remarkable progress in the past two decades, no remission is …
Cellular response to β‐amyloid neurotoxicity in Alzheimer's disease and implications in new therapeutics
Abstract β‐Amyloid (Aβ) is a specific pathological hallmark of Alzheimer's disease (AD).
Because of its neurotoxicity, AD patients exhibit multiple brain dysfunctions. Disease …
Because of its neurotoxicity, AD patients exhibit multiple brain dysfunctions. Disease …
Resveratrol induces autophagy and apoptosis in non-small-cell lung cancer cells by activating the NGFR-AMPK-mTOR pathway
J Li, Y Fan, Y Zhang, Y Liu, Y Yu, M Ma - Nutrients, 2022 - mdpi.com
Resveratrol (RSV) has been reported to induce autophagy and apoptosis in non-small-cell
lung cancer A549 cells, and the nerve growth factor receptor (NGFR) regulates autophagy …
lung cancer A549 cells, and the nerve growth factor receptor (NGFR) regulates autophagy …
NGFR Gene and Single Nucleotide Polymorphisms, rs2072446 and rs11466162, Playing Roles in Psychiatric Disorders
L Zhao, B Hou, L Ji, D Ren, F Yuan, L Liu, Y Bi, F Yang… - Brain Sciences, 2022 - mdpi.com
Psychiatric disorders are a class of complex disorders characterized by brain dysfunction
with varying degrees of impairment in cognition, emotion, consciousness and behavior …
with varying degrees of impairment in cognition, emotion, consciousness and behavior …
P75 neurotrophin receptor as a therapeutic target for drug development to treat neurological diseases
The interaction of neurotrophins with their receptors is involved in the pathogenesis and
progression of various neurological diseases, including Alzheimer's disease, Parkinson's …
progression of various neurological diseases, including Alzheimer's disease, Parkinson's …
The p75 neurotrophin receptor attenuates secondary thalamic damage after cortical infarction by promoting angiogenesis
L Peng, K Li, D Li, X Zuo, L Zhan… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Angiogenesis is crucial in neuroprotection of secondary thalamic injury after
cortical infarction. The p75 neurotrophin receptor (p75NTR) plays a key role in activating …
cortical infarction. The p75 neurotrophin receptor (p75NTR) plays a key role in activating …
P75 neurotrophin receptor controls subventricular zone neural stem cell migration after stroke
SS Deshpande, SC Malik, P Conforti, J Lin… - Cell and Tissue …, 2022 - Springer
Stroke is the leading cause of adult disability. Endogenous neural stem/progenitor cells
(NSPCs) originating from the subventricular zone (SVZ) contribute to the brain repair …
(NSPCs) originating from the subventricular zone (SVZ) contribute to the brain repair …
Human NGF “Painless” Ocular Delivery for Retinitis Pigmentosa: An In Vivo Study
D Napoli, N Orsini, G Salamone, MA Calvello… - Eneuro, 2024 - eneuro.org
Retinitis pigmentosa (RP) is a family of genetically heterogeneous diseases still without a
cure. Despite the causative genetic mutation typically not expressed in cone photoreceptors …
cure. Despite the causative genetic mutation typically not expressed in cone photoreceptors …
RELA is required for CD271 expression and stem-like characteristics in hypopharyngeal cancer
A Nakazato, M Mochizuki, R Shibuya-Takahashi… - Scientific Reports, 2022 - nature.com
CD271 (also referred to as nerve growth factor receptor or p75NTR) is expressed on cancer
stem cells in hypopharyngeal cancer (HPC) and regulates cell proliferation. Because …
stem cells in hypopharyngeal cancer (HPC) and regulates cell proliferation. Because …
Fading memories in aging and neurodegeneration: Is p75 neurotrophin receptor a culprit?
LW Wong, Z Wang, SRX Ang, S Sajikumar - Ageing Research Reviews, 2022 - Elsevier
Aging and age-related neurodegenerative diseases have become one of the major
concerns in modern times as cognitive abilities tend to decline when we get older. It is well …
concerns in modern times as cognitive abilities tend to decline when we get older. It is well …