Heat shock proteins (HSPs) are a large family of chaperones that are involved in protein
folding and maturation of a variety of “client” proteins protecting them from degradation …

Gastric cancer remains one of the most common cancers worldwide and one of the leading
cause for cancer-related deaths. Gastric adenocarcinoma is a multifactorial disease that is …

The processes of bone growth, modeling, and remodeling determine the structure, mass,
and biomechanical properties of the skeleton. Dysregulated bone resorption or bone …

Wnt signalling, a key pathway involved in various aspects of embryonic development, also
underlies many human diseases, in particular, cancer. Research focused on signal …

Clinical studies in a range of cancers have detected elevated levels of the Wnt antagonist
Dickkopf-1 (DKK1) in the serum or tumors of patients, and this was frequently associated …

Background & Aims Immune checkpoint blockade therapy benefits only a small subset of
patients with colorectal cancer (CRC), and identification of CRC-intrinsic events modulating …

Wnt signalling is a fundamental pathway involved in embryonic development and adult
tissue homeostasis. Mutations in the pathway frequently lead to developmental defects and …

Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of
advanced hepatocellular carcinoma (HCC). However, as the clinical application of sorafenib …

Heat shock proteins (HSPs) are a large molecular chaperone family classified by their
molecular weights, including HSP27, HSP40, HSP60, HSP70, HSP90, and HSP110. HSPs …

Leukemic cells can impact the bone marrow niche to create a tumor‐favorable
microenvironment using their secreted factors. Little knowledge is available about …