Cancer has reached pandemic dimensions in the whole world. Although current medicine
offers multiple treatment options against cancer, novel therapeutic strategies are needed …

In this work, we have developed covalent and low molecular weight docetaxel delivery
systems based on conjugation with N-acetyl-d-galactosamine and studied their properties …

One antitumor β-elemene derivative W-105 and three novel hepatocyte-targeting prodrugs
(W-1-5, W-2-9, and W-3-8) were designed and synthesized. W-105 (IC50 6.107 μM) could …

Targeted-drug administration to liver reduces side effects by minimising drug distribution to
non-target organs and increases therapeutic efficacy by boosting drug concentration in …

In the last decades, various efforts have been made to synthesize optimal glycotripods for
targeting trimeric glycoproteins like asialoglycoprotein receptor, hemagglutinin, and …

Herein, we describe the design, synthesis, and biological evaluation of novel betulin and N-
acetyl-d-galactosamine (GalNAc) glycoconjugates and suggest them as targeted agents …

Glycoconjugates forming from the conjugation of carbohydrates to other biomolecules, such
as proteins, lipids, or other carbohydrates, are essential components of mammalian cells …

The liver serves as the primary organ being responsible for metabolic processes and
detoxification, and is particularly susceptible to suffering injury. The degree of hepatic injury …

The liver is an organ with metabolism as the main function in the human body, and
participates in the body's function activities, including deoxidation, storage of liver glycogen …

Statins are effective 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-R) inhibitors,
which are successfully used for cardiovascular disease treatment. Statins' side effects are …