A fertilized egg is initially transcriptionally silent and relies on maternally provided factors to
initiate development. For embryonic development to proceed, the oocyte-inherited …

Understanding the processes and mechanisms underlying early human embryo
development has become an increasingly active and important area of research. It has …

Choline is a vital micronutrient. In this study, we aimed to confirm, and expand on previous
findings, how choline impacts embryos from the first 7 days of development to affect …

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

The type-I interferon (IFN) response constitutes the major innate immune pathway against
viruses in mammals. Despite its critical importance for antiviral defence, this pathway is …

Previous studies have shown cord-blood DNA methylation differences in newborns
conceived using assisted reproductive technologies (ART) compared to those conceived …

Research advances over the past 30 years have confirmed a critical role for genetics in the
etiology of dilated cardiomyopathies (DCMs). However, full knowledge of the genetic …

Early patterning of DNA methylation (DNAm) may play an important role in later disease
development. To better understand intergenerational epigenetic inheritance, we …

Polycomb group (PcG) proteins are a subset of epigenetic factors that are highly conserved
throughout evolution. In mammals, PcG proteins can be classified into two muti-proteins …

Interaction relationships are fundamental to the behavior of complex systems. This study,
grounded in Boolean discrete systems, conducts a comprehensive investigation of ordered …