Human placenta and trophoblast development: key molecular mechanisms and model systems

M Knöfler, S Haider, L Saleh, J Pollheimer… - Cellular and Molecular …, 2019 - Springer
Abnormal placentation is considered as an underlying cause of various pregnancy
complications such as miscarriage, preeclampsia and intrauterine growth restriction, the …

[HTML][HTML] Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders

S Rana, SD Burke, SA Karumanchi - American journal of obstetrics and …, 2022 - Elsevier
Preeclampsia is a devastating medical complication of pregnancy that can lead to significant
maternal and fetal morbidity and mortality. It is currently believed that there is abnormal …

The use of sex-specific factors in the assessment of women's cardiovascular risk

A Agarwala, ED Michos, Z Samad, CM Ballantyne… - Circulation, 2020 - Am Heart Assoc
Cardiovascular disease (CVD) is the leading cause of death among women in the United
States. As compared with men, women are less likely to be diagnosed appropriately, receive …

Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta

MK Jena, NR Sharma, M Petitt, D Maulik, NR Nayak - Biomolecules, 2020 - mdpi.com
Preeclampsia (PE) is a serious pregnancy complication, affecting about 5–7% of
pregnancies worldwide and is characterized by hypertension and damage to multiple …

Neurodevelopmental outcomes of prenatal preeclampsia exposure

SB Gumusoglu, ASS Chilukuri, DA Santillan… - Trends in …, 2020 - cell.com
Preeclampsia is a dangerous hypertensive disorder of pregnancy with known links to
negative child health outcomes. Here, we review epidemiological and basic neuroscience …

Preeclampsia: syndrome or disease?

L Myatt, JM Roberts - Current hypertension reports, 2015 - Springer
The focus on disease mechanisms underlying the hypertension and proteinuria defining
preeclampsia has increased knowledge of the pathophysiology yet we lack both therapy …

Integrated systems biology approach identifies novel maternal and placental pathways of preeclampsia

NG Than, R Romero, AL Tarca, KA Kekesi… - Frontiers in …, 2018 - frontiersin.org
Preeclampsia is a disease of the mother, fetus, and placenta, and the gaps in our
understanding of the complex interactions among their respective disease pathways …

Unsupervised placental gene expression profiling identifies clinically relevant subclasses of human preeclampsia

K Leavey, SJ Benton, D Grynspan, JC Kingdom… - …, 2016 - Am Heart Assoc
Preeclampsia (PE) is a complex, hypertensive disorder of pregnancy, demonstrating
considerable variability in maternal symptoms and fetal outcomes. Unfortunately, prior …

The prediction of preeclampsia: the way forward

L Myatt - American journal of obstetrics and gynecology, 2022 - Elsevier
Despite intensive investigation, we still cannot adequately predict, treat, or prevent
preeclampsia. We have gained awareness that preeclampsia is a syndrome not a disease …

[HTML][HTML] Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: The intersection of clinical, pathological, and high-dimensional biology …

NG Than, M Posta, D Györffy, L Orosz, G Orosz… - Placenta, 2022 - Elsevier
Preeclampsia is a syndromic disease of the mother, fetus, and placenta. The main limitation
in early and accurate diagnosis of preeclampsia is rooted in the heterogeneity of this …