Protein corona: a new approach for nanomedicine design

VH Nguyen, BJ Lee - International journal of nanomedicine, 2017 - Taylor & Francis
After administration of nanoparticle (NP) into biological fluids, an NP–protein complex is
formed, which represents the “true identity” of NP in our body. Hence, protein–NP interaction …

Nanoparticle uptake: the phagocyte problem

HH Gustafson, D Holt-Casper, DW Grainger… - Nano today, 2015 - Elsevier
Phagocytes are key cellular participants determining important aspects of host exposure to
nanomaterials, initiating clearance, biodistribution and the tenuous balance between host …

Antibiofouling polymer interfaces: poly (ethylene glycol) and other promising candidates

S Lowe, NM O'Brien-Simpson, LA Connal - Polymer Chemistry, 2015 - pubs.rsc.org
Nonspecific protein adsorption and/or microbial adsorption on biomedical materials
adversely affects the efficacy of a range of biomedical systems, from implants and …

Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking

X Duan, Y Li - Small, 2013 - Wiley Online Library
Nanoparticles have many potential applications in tumor therapy. Systemically administered
nanoparticles should remain in circulation for a long time to increase their accumulation in …

Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting

M Agrawal, S Saraf, S Saraf, SK Dubey, A Puri… - Journal of Controlled …, 2020 - Elsevier
In last two decades, the lipid nanocarriers have been extensively investigated for their drug
targeting efficiency towards the critical areas of the human body like CNS, cardiac region …

The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles

K Xiao, Y Li, J Luo, JS Lee, W Xiao, AM Gonik… - Biomaterials, 2011 - Elsevier
To systematically elucidate the effect of surface charge on the cellular uptake and in vivo fate
of PEG-oligocholic acid based micellar nanoparticles (NPs), the distal PEG termini of …

The journey of a drug-carrier in the body: an anatomo-physiological perspective

N Bertrand, JC Leroux - Journal of controlled release, 2012 - Elsevier
Recent advances in chemistry and material sciences have witnessed the emergence of an
increasing number of novel and complex nanosized carriers for the delivery of drugs and …

Magnetic iron oxide nanoparticles as drug carriers: clinical relevance

K El-Boubbou - Nanomedicine, 2018 - Taylor & Francis
Significant preclinical and clinical research has explored the use of magnetic iron oxide
nanoparticles (MNPs) for medical theranostics. Herein, we provide an overview of the …

Biopolymer-based microgels/nanogels for drug delivery applications

JK Oh, DI Lee, JM Park - Progress in polymer science, 2009 - Elsevier
Polysaccharide-based microgels/nanogels have high water content, functionality,
biocompatibility, tunable size from submicrons to tens of nanometers, large surface area for …

Nanoparticle–protein corona complexes govern the biological fates and functions of nanoparticles

C Gunawan, M Lim, CP Marquis, R Amal - Journal of Materials …, 2014 - pubs.rsc.org
Upon contact with plasma or other protein-containing biological fluids, the surface of
nanoparticles is immediately decorated with proteins forming a biologically active protein …