Impact of anxiety on prefrontal cortex encoding of cognitive flexibility

J Park, B Moghaddam - Neuroscience, 2017 - Elsevier
Anxiety often is studied as a stand-alone construct in laboratory models. But in the context of
coping with real-life anxiety, its negative impacts extend beyond aversive feelings and …

Integrating spatial working memory and remote memory: interactions between the medial prefrontal cortex and hippocampus

RA Wirt, JM Hyman - Brain sciences, 2017 - mdpi.com
In recent years, two separate research streams have focused on information sharing
between the medial prefrontal cortex (mPFC) and hippocampus (HC). Research into spatial …

Hierarchical control over effortful behavior by rodent medial frontal cortex: A computational model.

CB Holroyd, SM McClure - Psychological review, 2015 - psycnet.apa.org
The anterior cingulate cortex (ACC) has been the focus of intense research interest in recent
years. Although separate theories relate ACC function variously to conflict monitoring …

Rodent medial frontal control of temporal processing in the dorsomedial striatum

EB Emmons, BJ De Corte, Y Kim… - Journal of …, 2017 - Soc Neuroscience
Although frontostriatal circuits are critical for the temporal control of action, how time is
encoded in frontostriatal circuits is unknown. We recorded from frontal and striatal neurons …

Computational models of anterior cingulate cortex: At the crossroads between prediction and effort

E Vassena, CB Holroyd, WH Alexander - Frontiers in neuroscience, 2017 - frontiersin.org
In the last two decades the anterior cingulate cortex (ACC) has become one of the most
investigated areas of the brain. Extensive neuroimaging evidence suggests countless …

Dissociating the contributions of sensorimotor striatum to automatic and visually guided motor sequences

KGC Mizes, J Lindsey, GS Escola, BP Ölveczky - Nature Neuroscience, 2023 - nature.com
The ability to sequence movements in response to new task demands enables rich and
adaptive behavior. However, such flexibility is computationally costly and can result in …

Reconfiguration of Behavioral Signals in the Anterior Cingulate Cortex based on Emotional State

AJ Lindsay, I Gallello, BF Caracheo… - Journal of …, 2024 - Soc Neuroscience
Behaviors and their execution depend on the context and emotional state in which they are
performed. The contextual modulation of behavior likely relies on regions such as the …

Fluid network dynamics in the prefrontal cortex during multiple strategy switching

H Malagon-Vina, S Ciocchi, J Passecker… - Nature …, 2018 - nature.com
Coordinated shifts of neuronal activity in the prefrontal cortex are associated with strategy
adaptations in behavioural tasks, when animals switch from following one rule to another …

Dorsomedial striatal activity tracks completion of behavioral sequences in rats

Y Vandaele, DJ Ottenheimer, PH Janak - Eneuro, 2021 - eneuro.org
For proper execution of goal-directed behaviors, individuals require both a general
representation of the goal and an ability to monitor their own progress toward that goal …

A quantitative analysis of context-dependent remapping of medial frontal cortex neurons and ensembles

L Ma, JM Hyman, D Durstewitz, AG Phillips… - Journal of …, 2016 - Soc Neuroscience
The frontal cortex has been implicated in a number of cognitive and motivational processes,
but understanding how individual neurons contribute to these processes is particularly …