The intestinal barrier is a complex structure that allows the absorption of nutrients while
ensuring protection against intestinal pathogens and balanced immunity. The development …

Fibroblasts, derived from the embryonic mesenchyme, are a diverse array of cells with roles
in development, homeostasis, repair, and disease across tissues. In doing so, fibroblasts …

B cell zone reticular cells (BRCs) form stable microenvironments that direct efficient humoral
immunity with B cell priming and memory maintenance being orchestrated across lymphoid …

Fibroblastic reticular cells (FRCs) direct the interaction and activation of immune cells in
discrete microenvironments of lymphoid organs. Despite their important role in steering …

Fibroblastic reticular cells (FRCs) are specialized fibroblasts of secondary lymphoid organs
that provide the structural foundation of the tissue. Moreover, FRCs guide immune cells to …

Bioengineered models of human tissues have the potential to revolutionize human health by
providing a translational platform to investigate disease mechanisms and develop new …

Ovarian cancer (OC) has the lowest survival rate among gynecologic malignancies. Ectopic
lymphocyte aggregates, namely tertiary lymphoid structures (TLSs), have been reported as …

The deposition of immune complexes, activation of complement and infiltration of the kidney
by cells of the adaptive and innate immune systems have long been considered responsible …

Innate lymphoid cells (ILCs) govern immune cell homeostasis in the intestine and protect the
host against microbial pathogens. Various cell-intrinsic pathways have been identified that …

Mature lymphoid stromal cells (LSCs) are key organizers of immune responses within
secondary lymphoid organs. Similarly, inflammation-driven tertiary lymphoid structures …