Natural hydrogel-based bio-inks for 3D bioprinting in tissue engineering: a review

A Fatimi, OV Okoro, D Podstawczyk, J Siminska-Stanny… - Gels, 2022 - mdpi.com
Three-dimensional (3D) printing is well acknowledged to constitute an important technology
in tissue engineering, largely due to the increasing global demand for organ replacement …

Emerging tumor-on-chips with electrochemical biosensors

L Lei, B Ma, C Xu, H Liu - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
Cancer, one of the most dangerous diseases with a high mortality rate, has attracted much
attention and interest. Advances in tissue engineering and microfluidics have led to the …

Evaluation of biological activity of natural compounds: current trends and methods

C Barba-Ostria, SE Carrera-Pacheco… - Molecules, 2022 - mdpi.com
Natural compounds have diverse structures and are present in different forms of life.
Metabolites such as tannins, anthocyanins, and alkaloids, among others, serve as a defense …

In vitro models for non-alcoholic fatty liver disease: Emerging platforms and their applications

MJ Ramos, L Bandiera, F Menolascina, JA Fallowfield - Iscience, 2022 - cell.com
Non-alcoholic fatty liver disease (NAFLD) represents a global healthcare challenge,
affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form …

Role of patient-derived models of cancer in translational oncology

KF Idrisova, HU Simon, MO Gomzikova - Cancers, 2022 - mdpi.com
Simple Summary It was found that long-established tumor-derived cell lines do not
adequately reproduce drug sensitivity and behavior of a real human cancers. Therefore …

Current methods for studying metastatic potential of tumor cells

P Bouchalova, P Bouchal - Cancer cell international, 2022 - Springer
Cell migration and invasiveness significantly contribute to desirable physiological
processes, such as wound healing or embryogenesis, as well as to serious pathological …

[HTML][HTML] In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models

SY Lee, IS Koo, HJ Hwang, DW Lee - SLAS Discovery, 2023 - Elsevier
Abstract Three-dimensional (3D) cell culture technology has been steadily studied since the
1990's due to its superior biocompatibility compared to the conventional two-dimensional …

Recent methods of droplet microfluidics and their applications in spheroids and organoids

Y Wang, M Liu, Y Zhang, H Liu, L Han - Lab on a Chip, 2023 - pubs.rsc.org
Droplet microfluidic techniques have long been known as a high-throughput approach for
cell manipulation. The capacity to compartmentalize cells into picolitre droplets in …

Replacement, reduction, and refinement of animal experiments in anticancer drug development: the contribution of 3D in vitro cancer models in the drug efficacy …

EM Tosca, D Ronchi, D Facciolo, P Magni - Biomedicines, 2023 - mdpi.com
In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a
bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold …

Current approaches in CRISPR-Cas9 mediated gene editing for biomedical and therapeutic applications

G Bhattacharjee, N Gohil, K Khambhati, I Mani… - Journal of Controlled …, 2022 - Elsevier
A single gene mutation can cause a number of human diseases that affect the quality of life.
Until the development of clustered regularly interspaced short palindromic repeats …