The loss of germ cells and spermatogenic failure in non-obstructive azoospermia are
believed to be the main causes of male infertility. Laboratory studies have used in vitro …

Traditional therapeutic interventions aim to restore male fertile potential or preserve sperm
viability in severe cases, such as semen cryopreservation, testicular tissue, germ cell …

Three-dimensional (3D) hydrogel systems integrating different types of stem cells and
scaffolding biomaterials have an important application in tissue engineering. The biomimetic …

In modern life, several factors such as genetics, exposure to toxins, and aging have resulted
in significant levels of male infertility, estimated to be approximately 18% worldwide. In …

Cryopreserved testicular tissue offers a promising method to restore fertility in male infertility
patients. Current protocols rely on high concentrations of penetrating cryoprotectants …

The development of novel cell-based therapies has increased the necessity to improve the
long-term storage of cells. The current method of cryopreservation is far from optimal …

An in vitro spermatogonial stem cell (SSC) culture can serve as an effective technique to
study spermatogenesis and treatment for male infertility. In this research, we compared the …

The cryopreservation of spermatogonia stem cells (SSCs) has been widely used as an
alternative treatment for infertility. However, cryopreservation itself induces cryoinjury due to …

Pluripotent stem cells have the ability of self-renewal and pluripotency, which makes them
promising for application in cell therapy, tissue engineering and regenerative medicine …

Research question Which cryopreservation method better protects reproductive potential:
the cryopreservation of a testicular cell suspension (TCS) or the cryopreservation of …