[HTML][HTML] Benzimidazole and its derivatives: Recent Advances (2020–2022)

O Ebenezer, F Oyetunde-Joshua, OD Omotoso… - Results in …, 2023 - Elsevier
Benzimidazoles are fused heterocyclic ring systems containing two nitrogen atoms. They
have vital therapeutic significance in drug discovery. Many clinically approved drugs have …

[HTML][HTML] A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

LA Mohammed, MA Farhan, SA Dadoosh… - …, 2023 - thieme-connect.com
Benzimidazole is a heterocyclic compound that contains two nitrogen atoms and is formed
by fusing a benzene ring with an imidazole. Benzimidazole and its derivatives are prepared …

Jahn-Teller distortion in SP-like [Cu (bipy)(triamine)]. 2BF4 complexes with novel NH… F/CH… F synthon: XRD/HSA-interactions, physicochemical, electrochemical …

A AlAli, M Al-Noaimi, A AlObaid, HA Khamees… - Journal of Molecular …, 2023 - Elsevier
Abstract New [Cu (bipy)(NNN)]. 2BF 4 water soluble dicationic complexes were made
available starting from [Cu (bipy) 2 Br] Br. The two complexes were isolated in excellent yield …

Design, synthesis, characterization, docking studies of novel 4-phenyl acrylamide-1, 3-thiazole derivatives as anti-inflammatory and anti-ulcer agents

HM Pallavi, FH Al-Ostoot, VH Kameshwar… - Journal of Molecular …, 2023 - Elsevier
A great extent of nitrogen containing heterocyclic moiety comprising sulfur atom is
recognized as a valuable combination of therapeutics in medicinal chemistry. In particular …

Synthesis, molecular docking, analgesic, anti-inflammatory, and ulcerogenic evaluation of thiophene-pyrazole candidates as COX, 5-LOX, and TNF-α inhibitors

MJN Khadri, R Ramu, NA Simha, SA Khanum - Inflammopharmacology, 2024 - Springer
The thiophene bearing pyrazole derivatives (7a-j) were synthesized and examined for their
in vitro cyclooxygenase, 5-lipoxygenase, and tumour inducing factor-α inhibitory activities …

Multicomponent reaction for synthesis, molecular docking, and anti-inflammatory evaluation of novel indole-thiazole hybrid derivatives

F Alkorbi, SA Alshareef, MA Abdelaziz, N Omer… - Molecular Diversity, 2024 - Springer
In this article, novel thiazol-indolin-2-one derivatives 4a–f have been synthesized via
treatment of thiosemicarbazide (1) with some isatin derivative 2a–f and N-(4-(2-bromoacetyl) …

Evaluating the inhibitory activity of ferrocenyl Schiff bases derivatives on 5-lipoxygenase: Computational and biological studies

E Navarrete, P Morales, M Muñoz-Osses… - Journal of Inorganic …, 2023 - Elsevier
In the search for new 5-LOX inhibitors, two ferrocenyl Schiff base complexes functionalized
with catechol ((ƞ 5-(E)-C 5 H 4-Ndouble bondCH-3, 4-benzodiol) Fe (ƞ 5-C 5 H 5)(3a)) and …

SC-XRD investigation of Oh dicationic [CuII (Py2C (OH) 2) 2] 2+: A significant Jahn Teller distortion, 2D-S12/S9/S7 synthons, XRD/HSA-interactions, thermal …

A AlAli, K Shalalin, A Abu-Rayyan, H Khamees… - Journal of Molecular …, 2025 - Elsevier
Abstract Treating of Cu (NO 3) 2· 3H 2 O with di (pyridin-2-yl) methanone (Py 2 Cdouble
bondO) ligand resulted the [Cu II (Py 2 CO) 2](NO 3) 2 intermediate complex was first …

[HTML][HTML] Exploring the anticancer properties of indole pyrimidine derivatives: Synthesis, structural insights, docking analysis, and in vitro evaluation

HM Pallavi, VH Kameshwar, FH Al-Ostoot… - Chemical Physics …, 2024 - Elsevier
The nitrogen containing heterocyclic and chalcones moiety widely recognized as favorable
combination of diagnostic and therapeutic facilities in medicinal chemistry. In particular …

Synthesis, Biological Investigation, and Molecular Docking of Novel Benzimidazole‐Hydrazone Hybrids as Potential Anticancer Agent Candidates

S Demirci, TK Köprülü, A Mermer, GT Yılmaz - ChemistrySelect, 2024 - Wiley Online Library
In this study, six novel Benzimidazole‐hydrazone derivatives starting from the commercially
available 1H‐benzo [d] imidazole‐2‐amine were synthesized, and the molecular structure of …