The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …

Sequencing of nucleic acids with nanopores has emerged as a powerful tool offering rapid
readout, high accuracy, low cost and portability. This label-free method for sequencing at the …

Abstract Oxidative modification of 5-methylcytosine (5mC) by ten-eleven translocation (TET)
DNA dioxygenases generates 5-hydroxymethylcytosine (5hmC), the most abundant form of …

Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …

Existing single-cell bisulfite-based DNA methylation analysis is limited by low DNA recovery,
and the measurement of 5hmC at single-base resolution remains challenging. Here, we …

In the past decade, remarkable progress in cancer medicine has been achieved by the
development of treatments that target DNA sequence variants. However, a purely genetic …

Abstract Dynamic 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)
modifications to DNA regulate gene expression in a cell-type-specific manner and are …

Data from both bulk and single-cell whole-genome DNA methylation experiments are under-
utilized in many ways. This is attributable to inefficient mapping of methylation sequencing …

DNA methylation plays an important role in many biological processes. The mechanisms
underlying the establishment and maintenance of DNA methylation are well understood …

Epigenetic phenomena play a central role in cell regulatory processes and are important
factors for understanding complex human disease. One of the best understood epigenetic …