Genome-wide analysis of the biophysical properties of chromatin and nuclear proteins in living cells with Hi-D

CA Valades-Cruz, R Barth, M Abdellah, HA Shaban - Nature Protocols, 2024 - nature.com
To understand the dynamic nature of the genome, the localization and rearrangement of
DNA and DNA-binding proteins must be analyzed across the entire nucleus of single living …

Cell-size space regulates the behavior of confined polymers: from nano-and micromaterials science to biology

M Yanagisawa, C Watanabe, N Yoshinaga… - Langmuir, 2022 - ACS Publications
Polymer micromaterials in a liquid or gel phase covered with a surfactant membrane are
widely used materials in pharmaceuticals, cosmetics, and foods. In particular, cell-sized …

Ergodic characterization of nonergodic anomalous diffusion processes

M Mangalam, R Metzler, DG Kelty-Stephen - Physical Review Research, 2023 - APS
Anomalous diffusion in various complex systems abounds in nature and spans multiple
space and time scales. Canonical characterization techniques that rely upon mean squared …

Anomalous subdiffusion in living cells: Bridging the gap between experiments and realistic models through collaborative challenges

M Woringer, I Izeddin, C Favard, H Berry - Frontiers in Physics, 2020 - frontiersin.org
The life of a cell is governed by highly dynamical microscopic processes. Two notable
examples are the diffusion of membrane receptors and the kinetics of transcription factors …

Non-Gaussianity, population heterogeneity, and transient superdiffusion in the spreading dynamics of amoeboid cells

AG Cherstvy, O Nagel, C Beta, R Metzler - … Chemistry Chemical Physics, 2018 - pubs.rsc.org
What is the underlying diffusion process governing the spreading dynamics and search
strategies employed by amoeboid cells? Based on the statistical analysis of experimental …

Anomalous diffusion in time-fluctuating non-stationary diffusivity landscapes

AG Cherstvy, R Metzler - Physical Chemistry Chemical Physics, 2016 - pubs.rsc.org
We investigate the ensemble and time averaged mean squared displacements for particle
diffusion in a simple model for disordered media by assuming that the local diffusivity is both …

Biased continuous-time random walks for ordinary and equilibrium cases: facilitation of diffusion, ergodicity breaking and ageing

R Hou, AG Cherstvy, R Metzler… - Physical Chemistry …, 2018 - pubs.rsc.org
We examine renewal processes with power-law waiting time distributions (WTDs) and non-
zero drift via computing analytically and by computer simulations their ensemble and time …

Dynamics of nanoparticles in entangled polymer solutions

P Nath, R Mangal, F Kohle, S Choudhury… - Langmuir, 2018 - ACS Publications
The mean square displacement⟨ r 2⟩ of nanoparticle probes dispersed in simple isotropic
liquids and in polymer solutions is interrogated using fluorescence correlation spectroscopy …

Diffusing diffusivity: a new derivation and comparison with simulations

R Jain, KL Sebastian - Journal of Chemical Sciences, 2017 - Springer
Many experiments are now available where it has been shown that the probability
distribution function (pdf) for the position of a Brownian particle diffusing in a heterogeneous …

Test of the diffusing-diffusivity mechanism using near-wall colloidal dynamics

M Matse, MV Chubynsky, J Bechhoefer - Physical Review E, 2017 - APS
The mechanism of diffusing diffusivity predicts that, in environments where the diffusivity
changes gradually, the displacement distribution becomes non-Gaussian, even though the …