The AID/APOBEC polynucleotide cytidine deaminases have historically been classified as
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …

In order to promote an efficient humoral immune response, germinal center B cells modify
both the antigen recognition and effector domains by programmed genetic alterations of …

RNA-guided nucleases of the CRISPR/Cas type can be repurposed as programmable
nucleotide deaminases to mediate targeted nucleotide substitutions. Such base editors have …

Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype
switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic …

As B cells engage in the immune response, they express activation-induced cytidine
deaminase (AID) to initiate the hypermutation and recombination of immunoglobulin genes …

In response to an assault by foreign organisms, peripheral B cells can change their antibody
affinity and isotype by somatically mutating their genomic DNA. The ability of a cell to modify …

APOBEC1 is a cytidine deaminase that edits messenger RNAs and was the first enzyme in
the APOBEC family to be functionally characterized. Under appropriate conditions …

Cancer-initiating translocations such as those associated with lymphomas require the
formation of paired DNA double-strand breaks (DSBs). Activation-induced cytidine …

Studies of B cell lymphomas in the early 1980s led to the cloning of genes (c-MYC and IGH)
at a chromosome translocation breakpoint. A rush followed to identify recurrently …

Upon encountering antigens, mature IgM-positive B lymphocytes undergo class-switch
recombination (CSR) wherein exons encoding the default Cμ constant coding gene …