The polyadenosine RNA binding protein polyadenylate‐binding nuclear protein 1 (PABPN
1) plays key roles in post‐transcriptional processing of RNA. Although PABPN 1 is …

Intrinsically disordered proteins and proteins with intrinsically disordered regions have been
shown to be highly prevalent in disease. Furthermore, disease-causing expansions of the …

Processing of mRNA precursors (pre-mRNAs) by polyadenylation is an essential step in
gene expression. Polyadenylation consists of two steps, cleavage and poly (A) synthesis …

The number of patients with neurodegenerative diseases (NDs) is increasing, along with the
growing number of older adults. This escalation threatens to create a medical and social …

It has been 10 years since the identification of the first PABPN1 gene (GCN) n/polyalanine
mutations responsible for oculopharyngeal muscular dystrophy (OPMD). These mutations …

Abstract 3′ processing is an essential step in the maturation of all messenger RNAs
(mRNAs) and is a tightly coupled two‐step reaction: endonucleolytic cleavage at the poly (A) …

The nuclear poly (A) binding protein (PABPN1) has been suggested, on the basis of
biochemical evidence, to play a role in mRNA polyadenylation by strongly increasing the …

Publisher Summary Oculopharyngeal muscular dystrophy (OPMD) is a late-onset muscle
disease associated with progressive ptosis of the eyelids, dysphagia, and unique …

Genomic instability at loci with tandem arrays of simple repeats is the cause for many
neurological, neurodegenerative and neuromuscular diseases. When located in coding …

The family of scaffold attachment factor B (SAFB) proteins comprises three members and
was first identified as binders of the nuclear matrix/scaffold. Over the past two decades …