[HTML][HTML] A turn for the worse: Aβ β-hairpins in Alzheimer's disease

SM Ruttenberg, JS Nowick - Bioorganic & Medicinal Chemistry, 2024 - Elsevier
Amyloid-β (Aβ) oligomers are a cause of neurodegeneration in Alzheimer's disease (AD).
These soluble aggregates of the Aβ peptide have proven difficult to study due to their …

A β-barrel-like tetramer formed by a β-hairpin derived from Aβ

TD Samdin, CR Jones, G Guaglianone… - Chemical …, 2024 - pubs.rsc.org
β-Hairpins formed by the β-amyloid peptide Aβ are building blocks of Aβ oligomers. Three
different alignments of β-hairpins have been observed in the structures of Aβ oligomers or …

Generation and study of antibodies against two triangular trimers derived from Aβ

AG Kreutzer, RJ Malonis, CMT Parrocha… - Peptide …, 2024 - Wiley Online Library
Monoclonal antibodies (mAbs) that target the β‐amyloid peptide (Aβ) are important
Alzheimer's disease research tools and are now being used as Alzheimer's disease …