Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …

Sirtuins such as SIRT1 are conserved protein NAD+-dependent deacylases and thus their
function is intrinsically linked to cellular metabolism. Over the past two decades …

The sirtuins (SIRTs; of which there are seven in mammals) are NAD+-dependent enzymes
that regulate a large number of cellular pathways and forestall the progression of ageing …

Advancing age is the major risk factor for the development of chronic diseases and is
accompanied by changes in metabolic processes and mitochondrial dysfunction …

Sirtuins are NAD+-dependent deacetylase and deacylase enzymes that control important
cellular processes, including DNA damage repair, cellular metabolism, mitochondrial …

Sirtuins are NAD+-dependent protein deacylases that regulate several aspects of
metabolism and aging. In contrast to the other mammalian sirtuins, the primary enzymatic …

Sirtuins (SIRTs) are critical enzymes that govern genome regulation, metabolism, and aging.
Despite conserved deacetylase domains, mitochondrial SIRT4 and SIRT5 have little to no …

Mammalian cells use a specialized and complex machinery for the removal of altered
proteins or dysfunctional organelles. Such machinery is part of a mechanism called …