Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Background Migraine is a disabling and chronic neurovascular headache disorder.
Trigeminal vascular activation and release of calcitonin gene-related peptide (CGRP) play a …

The management of patients with migraine is often unsatisfactory because available acute
and preventive therapies are either ineffective or poorly tolerated. The acute treatment of …

Migraine is a common condition with disabling attacks that burdens people in the prime of
their working lives. Despite years of research into migraine pathophysiology and …

Background Monoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show
good prophylactic antimigraine efficacy. However, their site of action is still elusive. Due to …

Nitric oxide (NO) is a small gaseous signaling molecule that has important biological effects.
It has been heavily implicated in migraine; and the NO donor, nitroglycerin, has been used …

Migraine headache pathophysiology involves trigeminovascular system activation,
calcitonin gene-related peptide (CGRP) release, and dysfunctional nociceptive …

Nitric oxide (NO) is an important signaling molecule in the human body, playing a crucial
role in cell and neuronal communication, regulation of blood pressure, and in immune …

Migraine stands as one of the most disabling neurological conditions worldwide. It is a
disorder of great challenge to study given its heterogeneous representation, cyclic nature …

Migraine is a common and disabling neurological disorder, with several manifestations, of
which pain is just one. Despite its worldwide prevalence, there remains a paucity of targeted …