The extracellular matrix (ECM) is a complex network of macromolecules surrounding cells
providing structural support and stability to tissues. The understanding of the ECM and the …

The lysyl oxidase (LOX) family of oxidases contains a group of extracellular copper-
dependent enzymes that catalyze the cross-linking of collagen and elastin by oxidation, thus …

Cirrhosis is a severe form of liver fibrosis that results in the irreversible replacement of liver
tissue with scar tissue in the liver. Environmental toxicity, infections, metabolic causes, or …

microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either
blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in …

When hepatocytes are damaged severely, a variety of signaling pathways will be triggered
by inflammatory factors and cytokines involving in the process of hepatic fibrosis. The …

Introduction: Chronic fibrotic disorders are challenging clinical problems. The major
challenge is the identification of specific targets expressed selectively in fibrotic tissues …

Pulmonary fibrosis is a pathological condition in which lungs become scarred due to the
excess extracellular matrix (ECM) deposition and structural alterations in the interstitium of …

Primary open angle glaucoma (POAG), a chronic optic neuropathy, remains the leading
cause of irreversible blindness worldwide. It is driven in part by the pro-fibrotic cytokine …

Fibrosis is a common pathological state characterized by the excessive accumulation of
extracellular matrix components, but the pathogenesis of the disease is still not clear …

Different microRNAs (miRNAs), including miR-29 family, may play a role in the development
of heart failure (HF), but the underlying molecular mechanisms in HF pathogenesis remain …