The PPARα and PPARγ epigenetic landscape in cancer and immune and metabolic disorders

J Porcuna, J Mínguez-Martínez, M Ricote - International journal of …, 2021 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) are ligand-modulated nuclear
receptors that play pivotal roles in nutrient sensing, metabolism, and lipid-related processes …

Role of PPAR-allopregnanolone signaling in behavioral and inflammatory gut-brain axis communications

G Pinna - Biological Psychiatry, 2023 - Elsevier
The gut microbiome regulates emotional behavior, stress responses, and inflammatory
processes by communicating with the brain. How and which neurobiological mediators …

Maternal exercise-induced SOD3 reverses the deleterious effects of maternal high-fat diet on offspring metabolism through stabilization of H3K4me3 and protection …

J Kusuyama, NS Makarewicz, BG Albertson… - Diabetes, 2022 - Am Diabetes Assoc
Preclinical studies reveal maternal exercise as a promising intervention to reduce the
transmission of multigenerational metabolic dysfunction caused by maternal obesity. The …

The potential role of PPARs in the fetal origins of adult disease

J Guo, J Wu, Q He, M Zhang, H Li, Y Liu - Cells, 2022 - mdpi.com
The fetal origins of adult disease (FOAD) hypothesis holds that events during early
development have a profound impact on one's risk for the development of future adult …

Insights into the role of nucleotide methylation in metabolic-associated fatty liver disease

N Zhang, X Tian, T Yan, H Wang, D Zhang… - Frontiers in …, 2023 - frontiersin.org
Metabolic-associated fatty liver disease (MAFLD) is a chronic liver disease characterized by
fatty infiltration of the liver. In recent years, the MAFLD incidence rate has risen and emerged …

PPARα in the epigenetic driver seat of NAFLD: new therapeutic opportunities for epigenetic drugs?

C Theys, D Lauwers, C Perez-Novo, W Vanden Berghe - Biomedicines, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is a growing epidemic and the most common
cause of chronic liver disease worldwide. It consists of a spectrum of liver disorders ranging …

Effects of maternal advanced lipoxidation end products diet on the glycolipid metabolism and gut microbiota in offspring mice

W Pang, B Zhang, J Zhang, T Chen, Q Han… - Frontiers in …, 2024 - frontiersin.org
Introduction Dietary advanced lipoxidation end products (ALEs), which are abundant in heat-
processed foods, could induce lipid metabolism disorders. However, limited studies have …

Maternal fatty acid intake and human embryonic growth: the Rotterdam Periconception Cohort

E Rubini, L van Rossem, S Schoenmakers… - European Journal of …, 2024 - Springer
The required intake of macronutrients by women during the periconceptional period for
optimal fetal growth is the subject of ongoing investigation. Intake of polyunsaturated fatty …

The role of maternal DNA methylation in pregnancies complicated by gestational diabetes

S Dias, T Willmer, S Adam, C Pheiffer - Frontiers in Clinical Diabetes …, 2022 - frontiersin.org
Diabetes in pregnancy is associated with adverse pregnancy outcomes and poses a serious
threat to the health of mother and child. Although the pathophysiological mechanisms that …

Loss of NAT10 alleviates maternal high‐fat diet‐induced hepatic steatosis in male offspring of mice

QR Zhang, JB Zhang, F Shen, R Xue, RX Yang… - …, 2024 - Wiley Online Library
Objective Metabolic dysfunction‐associated steatotic liver disease (MASLD) is becoming an
escalating health problem in pediatric populations. This study aimed to investigate the role …