The study of hereditary cancer, which accounts for~ 10% of cancer cases worldwide is an
important subfield of oncology. Our understanding of hereditary cancers has greatly …

Background Elucidation of specific and recurrent/founder pathogenic variants (PVs) in
BRCA (BRCA1 and BRCA2) genes can make the genetic testing, for breast cancer (BC) …

Objective To investigate the prevalence and spectrum of BRCA1 and BRCA2 mutations in
Chinese Hakka patients with breast and ovarian cancer. Methods A total of 1,664 breast or …

Breast cancer (BC) is the most prevalent malignancy among women worldwide with
germline pathogenic variants/likely pathogenic variants (PVs/LPVs) in BRCA1/2 accounting …

Worldwide, ovarian cancer (OC) is one of the leading causes of cancer-related death among
women. Despite the recent progress in the treatment of advanced OC, oncologists in many …

Background Ovarian cancer is one of the most common gynecological malignancies. Due to
the absence of effective screening methods, ovarian cancer is usually diagnosed at late …

Objective To investigate the frequencies of BRCA1 and BRCA2 mutations in Chinese Hakka
patients with ovarian cancer. Methods The protein coding regions and exon intron boundary …

Objectives: The present study aimed to investigate the impact of BRCA1 protein expression
on the patients' outcome of ovarian serous carcinoma, and its correlation with different …

Background Patients with pathogenic sequence variants (PSVs) in BRCA1/BRCA2 are at
high risk of developing ovarian cancer (OC). However, genetic testing for BRCA1/BRCA2 …

Abstract Approximately 5%–10% of breast cancers are hereditary, caused by germline
pathogenic variants (GPVs) in breast cancer predisposition genes. To date, most studies of …