Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

T Guo, D Zhang, Y Zeng, TY Huang, H Xu… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

A review on recent approaches on molecular docking studies of novel compounds targeting acetylcholinesterase in Alzheimer disease

SC Peitzika, E Pontiki - Molecules, 2023 - mdpi.com
Alzheimer's disease (AD), a neurodegenerative brain disorder that affects millions of people
worldwide, is characterized by memory loss and cognitive decline. Low levels of …

Promoted CD4+ T cell-derived IFN-γ/IL-10 by photobiomodulation therapy modulates neurogenesis to ameliorate cognitive deficits in APP/PS1 and 3xTg-AD mice

X Wu, Q Shen, H Chang, J Li, D Xing - Journal of Neuroinflammation, 2022 - Springer
Background The immune system has been implicated in synaptic plasticity, inflammation,
and the progression of Alzheimer's disease (AD). However, there were few studies on …

Neuropeptides: Potential neuroprotective agents in ischemic injury

P Saklani, H Khan, S Gupta, A Kaur, TG Singh - Life Sciences, 2022 - Elsevier
Aim Ischemic damage to the brain is linked to an increased rate of morbidity and mortality
worldwide. In certain parts of the world, it remains a leading cause of mortality and the …

Hearing loss and cognitive impairment: epidemiology, common pathophysiological findings, and treatment considerations

A Bisogno, A Scarpa, S Di Girolamo, P De Luca… - Life, 2021 - mdpi.com
In recent years, there has been increasing research interest in the correlation between
hearing impairment and cognitive decline, two conditions that have demonstrated a strong …

Dysregulation of neuropeptide and tau peptide signatures in human Alzheimer's disease brain

S Podvin, Z Jiang, B Boyarko, LA Rossitto… - ACS Chemical …, 2022 - ACS Publications
Synaptic dysfunction and loss occur in Alzheimer's disease (AD) brains, which results in
cognitive deficits and brain neurodegeneration. Neuropeptides comprise the major group of …

Noise as a cause of neurodegenerative disorders: molecular and cellular mechanisms

AL Manukyan - Neurological Sciences, 2022 - Springer
Noise as an environmental stressor becomes of increasing importance in our industrialized
world, and especially traffic noise from the environment represents a potential novel …

Cholecystokinin octapeptide improves hippocampal glutamatergic synaptogenesis and postoperative cognition by inhibiting induction of A1 reactive astrocytes in …

L Chen, N Yang, Y Li, Y Li, J Hong… - CNS Neuroscience …, 2021 - Wiley Online Library
Aims Delayed neurocognitive recovery (dNCR) is a common postoperative complication in
geriatric surgical patients for which there is no efficacious therapy. Cholecystokinin …

Nutraceuticals-based therapeutic approach: Recent advances to combat pathogenesis of Alzheimer's disease

M Talebi, E Kakouri, M Talebi, PA Tarantilis… - Expert review of …, 2021 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is a progressive neurodegenerative disease
accompanying memory deficits. The available pharmaceutical care has some limitations …

Identification of hub genes associated with cognition in the hippocampus of Alzheimer's Disease

YJ Liu, TT Liu, LH Jiang, Q Liu, ZL Ma, TJ Xia… - …, 2021 - Taylor & Francis
Alzheimer's Disease (AD) is a neurodegenerative disease featured by cognitive impairment.
This bioinformatic analysis was used to identify hub genes related to cognitive dysfunction in …