There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has
many roles in female and male reproduction, as a neuropeptide in the central nervous …

Relaxin has vital physiological roles in pregnant rats, mice, and pigs. Relaxin promotes
growth and softening of the cervix, thus facilitating rapid delivery of live young. Relaxin also …

Many see the periaqueductal gray (PAG) as a region responsible for the downstream control
of defensive reactions. Here we provide a detailed review of anatomical and functional data …

Several orphan G protein-coupled receptors homologous to gonadotropin and thyrotropin
receptors have recently been identified and named as LGR4–8. INSL3, also known as …

GPCR135, publicly known as somatostatin-and angiotensin-like peptide receptor, is
expressed in the central nervous system and its cognate ligand (s) has not been identified …

Cardiac fibrosis is a key component of heart disease and involves the proliferation and
differentiation of matrix-producing fibroblasts. The effects of an antifibrotic peptide hormone …

Although the hormone relaxin was discovered 80 years ago, only in the past 5 years have
the receptors for relaxin and three other receptors that respond to related peptides been …

Relaxin 3/INSL 7 has recently been identified as a new member of the insulin/relaxin
superfamily. Although it was reported to be dominantly expressed in the brain, its detailed …

Leucine-rich repeat-containing, G protein-coupled receptors (LGRs) represent a unique
subgroup of G protein-coupled receptors with a large ectodomain. Recent studies …

Abstract Lymphocystis disease virus-1 (LCDV-1) and several other Iridoviridae encode viral
insulin/IGF-1 like peptides (VILPs) with high homology to human insulin and IGFs. Here we …