The morbidity and mortality from cardiovascular diseases (CVD) remain high. Metabolic
diseases such as obesity, hyperlipidemia, diabetes mellitus (DM), non-alcoholic fatty liver …

Hypoxia, the decline of tissue oxygen stress, plays a role in mediating cellular processes.
Cardiovascular disease, relatively widespread with increased mortality, is closely correlated …

Background/purpose Roxadustat, a first-in-class hypoxia-inducible factor prolyl hydroxylase
inhibitor, promotes erythropoiesis and regulates iron metabolism. This study investigated the …

Hypoxia-inducible factor prolyl 4-hydroxylases (HIF-P4Hs, also known as PHDs or EglNs)
are enzymes that act as cellular oxygen sensors. Inhibition of HIF-P4Hs leads to stabilization …

Hypoxia of residence at high altitude (> 2500 m) decreases birth weight. Lower birth weight
associates with infant mortality and morbidity and increased susceptibility to later-in-life …

Prolyl hydroxylase (PH) enzymes control the degradation of hypoxia-inducible factor (HIF), a
transcription factor known to regulate erythropoiesis, angiogenesis, glucose metabolism, cell …

Alcoholic fatty liver disease (AFLD) is a growing health problem for which no targeted
therapy is available. We set out to study whether systemic inactivation of the main hypoxia …

Objective Intrinsic inflammatory characteristics play a pivotal role in stem cell recruitment
and homing through migration where the subsequent change in niche has been shown to …

Non-alcoholic fatty liver disease (NAFLD) parallels the global obesity epidemic with unmet
therapeutic needs. We investigated whether inhibition of hypoxia-inducible factor prolyl 4 …

Background Globally, one in ten babies is born preterm (< 37 weeks), and 1–2% preterm at
very low birth weight (VLBW,< 1500 g). As adults, they are at increased risk for a plethora of …