[HTML][HTML] The novel role of PPAR alpha in the brain: promising target in therapy of Alzheimer's disease and other neurodegenerative disorders
S Wójtowicz, AK Strosznajder, M Jeżyna… - Neurochemical …, 2020 - Springer
Peroxisome proliferator activated receptor alpha (PPAR-α) belongs to the family of ligand-
regulated nuclear receptors (PPARs). These receptors after heterodimerization with retinoid …
regulated nuclear receptors (PPARs). These receptors after heterodimerization with retinoid …
[HTML][HTML] The endocannabinoid system and PPARs: Focus on their signalling crosstalk, action and transcriptional regulation
FA Iannotti, RM Vitale - Cells, 2021 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors
including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the …
including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the …
Prenatal THC exposure produces a hyperdopaminergic phenotype rescued by pregnenolone
The increased legal availability of cannabis has led to a common misconception that it is a
safe natural remedy for, among others, pregnancy-related ailments such as morning …
safe natural remedy for, among others, pregnancy-related ailments such as morning …
Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability
Nicotine stimulates brain reward circuitries, most prominently the mesocorticolimbic
dopamine system, and this action plays a critical in establishing and maintaining the tobacco …
dopamine system, and this action plays a critical in establishing and maintaining the tobacco …
Palmitoylethanolamide in CNS health and disease
GM Raso, R Russo, A Calignano, R Meli - Pharmacological Research, 2014 - Elsevier
The existence of acylethanolamides (AEs) in the mammalian brain has been known for
decades. Among AEs, palmitoylethanolamide (PEA) is abundant in the central nervous …
decades. Among AEs, palmitoylethanolamide (PEA) is abundant in the central nervous …
[HTML][HTML] A cholinergic circuit that relieves pain despite opioid tolerance
S Sullere, A Kunczt, DS McGehee - Neuron, 2023 - cell.com
Chronic pain is a tremendous burden for afflicted individuals and society. Although opioids
effectively relieve pain, significant adverse outcomes limit their utility and efficacy. To …
effectively relieve pain, significant adverse outcomes limit their utility and efficacy. To …
Prenatal and childhood exposure to per-and polyfluoroalkyl substances (PFASs) and child cognition
Background Per-and polyfluoroalkyl substances (PFASs) are suspected developmental
toxicants, but epidemiological evidence on neurodevelopmental effects of PFAS exposure is …
toxicants, but epidemiological evidence on neurodevelopmental effects of PFAS exposure is …
Neuroprotective properties of peroxisome proliferator-activated receptor alpha (PPARα) and its lipid ligands
M Fidaleo, F Fanelli, M Paola Ceru… - Current medicinal …, 2014 - ingentaconnect.com
Signalling lipids are known to control a wide array of cellular processes, including cell
proliferation, apoptosis, migration, and energy metabolism. Fatty acids and their derivatives …
proliferation, apoptosis, migration, and energy metabolism. Fatty acids and their derivatives …
Role of nicotinic acetylcholine receptors in regulating dopamine neuron activity
Midbrain dopamine (DA) neurons play a central role in a wide range of behaviors, from
attention and motivation to motor control and reinforcement. The release of DA is modulated …
attention and motivation to motor control and reinforcement. The release of DA is modulated …
Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with two major
behavioral symptoms ie repetitive behavior and social-communication impairment. The …
behavioral symptoms ie repetitive behavior and social-communication impairment. The …