An imbalance in oxygen supply and demand......................................................................... 337
Experimental evidence for possible mechanisms of benefit from beta blockade in acute MI …

Meta-analysis, the statistical combination of results from several studies to produce a single
estimate of the effect of a treatment, continues to attract controversy. We illustrate the …

The effect of metoprolol on mortality was compared with that of placebo in a double-blind
randomised trial in patients with definite or suspected acute myocardial infarction. Treatment …

Background Debate exists about the efficacy of β-blockers in myocardial infarction and their
required duration of usage in contemporary practice. Methods We conducted a …

Context Cardiovascular disease (CVD) risk increases beginning at systolic blood pressure
levels of 115 mm Hg. Use of antihypertensive medications among patients with a history of …

Heart rate after an acute myocardial infarction (AMI) is an index of late mortality. The
hypothesis—that the potential beneficial effect of β-blocking drugs after an AMI is …

Aims The impact on mortality outcomes of beta-blockers and calcium blockers in post-
myocardial infarction (MI) has been suggested to be related to resting heart rate (HR) …

In a multicentre double-blind randomised study, the effect of sotalol 320 mg once daily was
compared with that of placebo in patients surviving an acute myocardial infarction …

β-Adrenergic blockers are one of the most frequently prescribed cardiovascular drugs.
Numerous β-blockers are available for clinical use. Although these agents differ …

Seventy-seven patients undergoing elective cardiac catheterization were administered a
diagnostic psychiatric interview and their mean heart rates and heart rate variability were …