Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment.
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …

Boron-containing molecules have been extensively used for the purposes of chemical
sensing, biological probe development and drug discovery. Due to boron's empty p orbital, it …

Proteases form one of the largest and more important groups of enzymes. They selectively
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …

Tissue kallikreins are a family of fifteen secreted serine proteases encoded by the largest
protease gene cluster in the human genome. In the past decade, substantial progress has …

Advances in the field of boron chemistry have expanded the application of boron from
material use to medicine. Boron-based drugs represent a new class of molecules that …

In 2003, bortezomib, a first-in-class therapeutic, gained approval from the US Federal Drug
Administration for the treatment of relapsed multiple myeloma and mantle cell lymphoma …

α-Aminoboronic acids and their derivatives are useful as bioactive agents. Thus far, three
compounds containing an α-aminoboronate motif have been approved by the Food and …

The prostate-specific antigen (PSA) blood test is the accepted biomarker of tumor
recurrence. PSA levels in serum correlate with disease progression, though its diagnostic …

Including the true tissue kallikrein KLK1, kallikrein-related peptidases (KLKs) represent a
family of fifteen mammalian serine proteases. While the physiological roles of several KLKs …

Although boronic acids have attracted considerable interest as versatile intermediates in
organic synthesis, their contributions in chemical biology and drug discovery programs have …