Targeting persistent changes in neuroimmune and epigenetic signaling in adolescent drinking to treat alcohol use disorder in adulthood
Studies universally find early age of drinking onset is linked to lifelong risks of alcohol
problems and alcohol use disorder (AUD). Assessment of the lasting effect of drinking during …
problems and alcohol use disorder (AUD). Assessment of the lasting effect of drinking during …
[HTML][HTML] Sex-and age-specific effects on the development of addiction and compulsive-like drinking in rats
Background Biological factors are known to influence disease trajectories and treatment
effectiveness in alcohol addiction and preclinical and clinical evidence suggests that sex is …
effectiveness in alcohol addiction and preclinical and clinical evidence suggests that sex is …
Sex differences in the effects of adolescent intermittent ethanol exposure on exploratory and anxiety-like behavior in adult rats
KL Healey, SA Kibble, A Bell, G Kramer… - Alcohol, 2022 - Elsevier
Adolescent intermittent ethanol (AIE) exposure in rodents has been shown to alter adult
behavior in several domains, including learning and memory, social interaction, affective …
behavior in several domains, including learning and memory, social interaction, affective …
[HTML][HTML] Impact of adolescent intermittent ethanol exposure on social investigation, social preference, and neuronal activation in cFos-LacZ male and female rats
TT Towner, DT Applegate, EI Varlinskaya… - Frontiers in …, 2022 - frontiersin.org
Adolescence is a sensitive developmental period during which alcohol use is often initiated
and consumed in high quantities, often at binge or even high-intensity drinking levels. Our …
and consumed in high quantities, often at binge or even high-intensity drinking levels. Our …
[HTML][HTML] Epigenetic regulation of microglia and neurons by proinflammatory signaling following adolescent intermittent ethanol (AIE) exposure and in human AUD
Adolescent alcohol drinking is linked to high rates of adult alcohol problems and alcohol use
disorder (AUD). The Neurobiology of Alcohol Drinking in Adulthood (NADIA) consortium …
disorder (AUD). The Neurobiology of Alcohol Drinking in Adulthood (NADIA) consortium …
[HTML][HTML] Acute alcohol induces greater dose-dependent increase in the lateral cortical network functional connectivity in adult than adolescent rats
Alcohol misuse and, particularly adolescent drinking, is a major public health concern. While
evidence suggests that adolescent alcohol use affects frontal brain regions that are …
evidence suggests that adolescent alcohol use affects frontal brain regions that are …
Adolescent intermittent ethanol exposure enhances adult stress effects in male rats
KL Healey, S Kibble, K Dubester, A Bell… - Pharmacology …, 2023 - Elsevier
Binge patterns of alcohol use, prevalent among adolescents, are associated with a higher
probability of developing alcohol use disorders (AUD) and other psychiatric disorders, like …
probability of developing alcohol use disorders (AUD) and other psychiatric disorders, like …
Determining the neuronal ensembles underlying sex-specific social impairments following adolescent intermittent ethanol exposure
TT Towner, MA Goyden, HJ Coleman, MK Drumm… - …, 2023 - Elsevier
Binge drinking during adolescence can have behavioral and neurobiological
consequences. We have previously found that adolescent intermittent ethanol (AIE) …
consequences. We have previously found that adolescent intermittent ethanol (AIE) …
The influence of sex on hippocampal neurogenesis and neurotrophic responses on the persistent effects of adolescent intermittent ethanol exposure into adulthood
KN Nwachukwu, KL Healey, HS Swartzwelder… - Neuroscience, 2022 - Elsevier
Abstract In the United States, approximately 90% of alcohol consumed by adolescents is
binge drinking. Binge-like ethanol exposure during adolescence promotes dysregulation of …
binge drinking. Binge-like ethanol exposure during adolescence promotes dysregulation of …
[HTML][HTML] Adolescent alcohol exposure persistently alters orbitofrontal cortical encoding of Pavlovian conditional stimulus components in female rats
Exposure to alcohol during adolescence impacts cortical and limbic brain regions
undergoing maturation. In rodent models, long-term effects on behavior and …
undergoing maturation. In rodent models, long-term effects on behavior and …