Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Despite the significant advances in neurology, the cure for neurodegenerative conditions
remains a formidable task to date. Among various factors arising from the complex etiology …

Therapeutic strategies for neurodegenerative disorders have commonly targeted individual
aspects of the disease pathogenesis to little success. Neurodegenerative diseases …

Inflammation clearly occurs in pathologically vulnerable regions of the Alzheimer's disease
(AD) brain, and it does so with the full complexity of local peripheral inflammatory responses …

The drug efflux transporters ABCB1 and ABCG2 at the blood-brain barrier limit the delivery
of drugs into the brain. Strategies to overcome ABCB1/ABCG2 have been largely …

While peripheral immune access to the central nervous system (CNS) is restricted and tightly
controlled, the CNS is capable of dynamic immune and inflammatory responses to a variety …

Background Resolution is the final stage of the inflammatory response, when restoration of
tissue occurs. Failure may lead to chronic inflammation, which is known as part of the …

Generation and deposition of amyloid beta peptides and neurofibrillary tangle formation are
key mechanisms involved in AD pathogenesis. Recent evidence suggests that inflammatory …

Generation of neurotoxic amyloid β peptides and their deposition along with neurofibrillary
tangle formation represent key pathological hallmarks in Alzheimer's disease (AD). Recent …

The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized
by activated glial cells and increased expression of cytokines and complement factors …