Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

The use of deep machine learning (ML) in protein structure prediction has made it possible
to easily access a large number of annotated conformations that can potentially compensate …

Highlights•GPCRs can form homodimers or heterodimers; these complexes regulate a wide
range of physiological and pathological functions and are emerging drug targets.•The …

Chronic pain is a hallmark of functional disorders, inflammatory diseases and cancer of the
digestive system. The mechanisms that initiate and sustain chronic pain are incompletely …

G protein-coupled receptors (GPCRs) regulate a wide range of physiological and
pathophysiological cellular processes, thus it is important to understand how GPCRs are …

With over 30% of current medications targeting this family of proteins, G-protein–coupled
receptors (GPCRs) remain invaluable therapeutic targets. However, due to their unique …

G protein-coupled receptors (GPCRs) are the target of hundreds of approved drugs.
Although these drugs were designed to target individual receptors, it is becoming …

G protein-coupled receptors (GPCRs) have the propensity to form homo-and heterodimers.
Dysfunction of these dimers has been associated with multiple diseases, eg, pre-eclampsia …

Wistar-Kyoto rats (WKY), compared to Wistar rats, are a well-validated animal model for drug-
resistant depression. Thanks to this, they can provide information on the potential …

Background Previously, we reported that cysteine‐rich secretory protein 2 is involved in high
molecular weight complexes in boar spermatozoa. These cysteine‐rich secretory protein …