Multifunctional hydrogels based on chitosan, hyaluronic acid and other biological macromolecules for the treatment of inflammatory bowel disease: A review

Y Ouyang, J Zhao, S Wang - International journal of biological …, 2023 - Elsevier
Hydrogel is a three-dimensional network polymer material rich in water. It is widely used in
the biomedical field because of its unique physical and chemical properties and good …

IBD disease-modifying therapies: insights from emerging therapeutics

NG Kotla, Y Rochev - Trends in Molecular Medicine, 2023 - cell.com
Inflammatory bowel disease (IBD) pathogenesis is associated with gut mucosal
inflammation, epithelial damage, and dysbiosis leading to a dysregulated gut mucosal …

[HTML][HTML] Gold nanoparticles-embedded ceria with enhanced antioxidant activities for treating inflammatory bowel disease

M Li, J Liu, L Shi, C Zhou, M Zou, D Fu, Y Yuan, C Yao… - Bioactive Materials, 2023 - Elsevier
The excessive reactive oxygen species (ROS) is a hallmark associated with the initiation
and progression of inflammatory bowel disease (IBD), which execrably form a vicious cycle …

A Curcumin‐Modified Coordination Polymers with ROS Scavenging and Macrophage Phenotype Regulating Properties for Efficient Ulcerative Colitis Treatment

H Yao, F Wang, H Chong, J Wang, Y Bai… - Advanced …, 2023 - Wiley Online Library
Overexpression of classically activated macrophages (M1) subtypes and assessed reactive
oxygen species (ROS) levels are often observed in patients with ulcerative colitis. At present …

[HTML][HTML] Inflammation-specific targeted carriers for local drug delivery to inflammatory bowel disease

NG Kotla, R Singh, BV Baby, S Rasala, J Rasool… - Biomaterials, 2022 - Elsevier
Delivering drugs directly to the inflamed intestinal sites to treat inflammatory bowel disease
(IBD), particularly Crohn's and ulcerative colitis, is highly challenging. Recent advances in …

The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease

T Mukherjee, N Kumar, M Chawla, DJ Philpott… - Science …, 2024 - science.org
Inflammatory bowel disease (IBD) is an idiopathic, chronic condition characterized by
episodes of inflammation in the gastrointestinal tract. The nuclear factor κB (NF-κB) system …

Structurally dynamic self-healable hydrogel cooperatively inhibits intestinal inflammation and promotes mucosal repair for enhanced ulcerative colitis treatment

X Ge, H Wen, Y Fei, R Xue, Z Cheng, Y Li, K Cai, L Li… - Biomaterials, 2023 - Elsevier
Hydrogels are a class of biocompatible materials with versatile functions that have been
increasing explored for the localized treatment of ulcerative colitis (UC), but various …

Egg yolk phosphatidylcholine alleviates DSS-induced colitis in BALB/c mice

Y Wen, L Tan, S Chen, N Wu, Y Yao, L Xu, M Xu… - Food & Function, 2023 - pubs.rsc.org
Ulcerative colitis (UC) is a common inflammatory bowel disease, whose incidence is on the
rise worldwide. The drugs commonly used for UC are often associated with a number of side …

20(S)‐ Protopanaxadiol saponins isolated from Panax notoginseng target the binding of HMGB1 to TLR4 against inflammation in experimental ulcerative colitis

J Chen, P Lu, J Liu, L Yang, Y Li, Y Chen… - Phytotherapy …, 2023 - Wiley Online Library
Ulcerative colitis (UC) has emerged as a global healthcare issue due to high prevalence
and unsatisfying therapeutic measures. 20 (S)‐Protopanaxadiol saponins (PDS) from Panax …

Closed-loop theranostic microgels for immune microenvironment modulation and microbiota remodeling in ulcerative colitis

Z Jin, Y Zhang, H Hu, Q Li, L Zhang, K Zhao, W Liu, L Li… - Biomaterials, 2025 - Elsevier
Inflammatory bowel disease (IBD) is characterized by the upregulation of reactive oxygen
species (ROS) and dysfunction of gut immune system, and microbiota. The conventional …