Positron emission tomography (PET) is an important driver for present day healthcare.
Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview …

Positron emission tomography (PET) is a modern in vivo imaging technique and an
important diagnostic modality for clinical and pre-clinical research. The incorporation of a …

Recent reports suggest that an increasing number of patients with lung cancer, especially
those with activating mutations of the epidermal growth factor receptor (EGFR), also present …

Introduction Afatinib is an irreversible ErbB family blocker that was approved for the
treatment of EGFR mutated non-small cell lung cancer in 2013. Positron emission …

Pieces of data on the synthesis and antitumour activity of 4-aminoquinazolines are
summarized and analyzed. Key methods for the synthesis of these compounds are …

Herein, we demonstrate a continuous flow synthesis method for 4-(3-chloro-4-
fluorophenylamino)-6-hydroxy-7-methoxyquinazoline, a key intermediate of Gefitinib and …

Abstract The reference standard AZD8931 {2-(4-((4-((3-chloro-2-fluorophenyl) amino)-7-
methoxyquinazolin-6-yl) oxy) piperidin-1-yl)-N-methylacetamide}(11a) was synthesized from …

分子成像可在活体状态下直观判断分子靶向药物靶位点存在状态, 分子靶向药物与靶位点结合率
及精确监测分子靶向药物的治疗疗效, 为临床治疗方案的选择和调整提供依据. EGFR …

The iodine-catalyzed reaction of 2-amino-N′-arylbenzohydrazides and haloketones was
carried out in ionic liquids and was found in good chemoselectivity. 5-Chloropentan-2-one …

Обобщены и проанализированы данные по синтезу и противоопухолевой активности 4-
аминохиназолинов. Рассмотрены важнейшие методы синтеза таких соединений, в …