[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
Heat shock factors: integrators of cell stress, development and lifespan
M Åkerfelt, RI Morimoto, L Sistonen - Nature reviews Molecular cell …, 2010 - nature.com
Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute
stress. They are best known as inducible transcriptional regulators of genes encoding …
stress. They are best known as inducible transcriptional regulators of genes encoding …
Reversible phase separation of HSF1 is required for an acute transcriptional response during heat shock
H Zhang, S Shao, Y Zeng, X Wang, Y Qin, Q Ren… - Nature cell …, 2022 - nature.com
Heat-shock transcription factor 1 (HSF1) orchestrates the fast and vast cellular response to
heat shock through increased expression of heat-shock proteins. However, how HSF1 …
heat shock through increased expression of heat-shock proteins. However, how HSF1 …
Paraspeckles: a novel nuclear domain
Background: The cell nucleus contains distinct classes of subnuclear bodies, including
nucleoli, splicing speckles, Cajal bodies, gems, and PML bodies. Many nuclear proteins are …
nucleoli, splicing speckles, Cajal bodies, gems, and PML bodies. Many nuclear proteins are …
Lnc RNA‐dependent nuclear stress bodies promote intron retention through SR protein phosphorylation
A number of long noncoding RNA s (lnc RNA s) are induced in response to specific stresses
to construct membrane‐less nuclear bodies; however, their function remains poorly …
to construct membrane‐less nuclear bodies; however, their function remains poorly …
Nuclear stress bodies
G Biamonti, C Vourc'h - Cold Spring Harbor perspectives …, 2010 - cshperspectives.cshlp.org
Nuclear stress bodies (nSBs) are unique subnuclear organelles which form in response to
heat shock. They are initiated through a direct interaction between heat shock transcription …
heat shock. They are initiated through a direct interaction between heat shock transcription …
HuR binding to cytoplasmic mRNA is perturbed by heat shock
IE Gallouzi, CM Brennan… - Proceedings of the …, 2000 - National Acad Sciences
AU-rich elements (AREs) located in the 3′ untranslated region target the mRNAs encoding
many protooncoproteins, cytokines, and lymphokines for rapid degradation. HuR, a …
many protooncoproteins, cytokines, and lymphokines for rapid degradation. HuR, a …
Lifespan extension in C. elegans caused by bacterial colonization of the intestine and subsequent activation of an innate immune response
Mechanisms that control aging are important yet poorly defined. To discover longevity
control genes, we performed a forward genetic screen for delayed reproductive aging in C …
control genes, we performed a forward genetic screen for delayed reproductive aging in C …
The role of AUF1 in regulated mRNA decay
FM Gratacós, G Brewer - Wiley Interdisciplinary Reviews: RNA, 2010 - Wiley Online Library
Messenger ribonucleic acid (mRNA) turnover is a major control point in gene expression. In
mammals, many mRNAs encoding inflammatory cytokines, oncoproteins, and G‐protein …
mammals, many mRNAs encoding inflammatory cytokines, oncoproteins, and G‐protein …
The Arabidopsis cyclophilin gene family
Database searching has allowed the identification of a number of previously unreported
single and multidomain isoform members of the Arabidopsis cyclophilin gene family. In …
single and multidomain isoform members of the Arabidopsis cyclophilin gene family. In …