The objective of this manuscript is to provide quantitative insights into the tissue distribution
of nanoparticles. Published pharmacokinetics of nanoparticles in plasma, tumor and 13 …

Polymeric nanoparticles (NP s) are one of the most studied organic strategies for
nanomedicine. Intense interest lies in the potential of polymeric NP s to revolutionize …

Nanomaterials (NMs) have been increasingly used in a number of areas, including
consumer products and nanomedicine. Target tissue dosimetry is important in the evaluation …

With the great interests in the discovery and development of drug products containing
nanoparticles, there is a great demand of quantitative tools for assessing quality, safety, and …

Insufficient data on nano-and microplastics (NMP) hinder robust evaluation of their potential
health risks. Methodological disparities and the absence of established toxicity thresholds …

Highlights•PBPK modeling bridges drug properties and PK behaviours in drug discovery
and development.•The PBPK is often used in oral formulation development, to address …

To assess the potential toxicity of nanoparticles (NPs), information concerning their uptake
and disposition (biokinetics) is essential. Experience with industrial chemicals and …

There have been efforts to develop physiologically based pharmacokinetic (PBPK) models
for nanomaterials (NMs). Since NMs have quite different kinetic behaviors, the applicability …

Despite recent advances in the translation of therapeutic nanoparticles (TNPs) into the clinic,
the field continues to face challenges in predictably and selectively delivering nanomaterials …

Cancer treatment and pharmaceutical development require targeted treatment and less toxic
therapeutic intervention to achieve real progress against this disease. In this scenario …