[HTML][HTML] Nanoparticle biodistribution coefficients: A quantitative approach for understanding the tissue distribution of nanoparticles
The objective of this manuscript is to provide quantitative insights into the tissue distribution
of nanoparticles. Published pharmacokinetics of nanoparticles in plasma, tumor and 13 …
of nanoparticles. Published pharmacokinetics of nanoparticles in plasma, tumor and 13 …
Polymeric nanoparticles: the future of nanomedicine
Polymeric nanoparticles (NP s) are one of the most studied organic strategies for
nanomedicine. Intense interest lies in the potential of polymeric NP s to revolutionize …
nanomedicine. Intense interest lies in the potential of polymeric NP s to revolutionize …
Integration of in vitro and in vivo models to predict cellular and tissue dosimetry of nanomaterials using physiologically based pharmacokinetic modeling
Nanomaterials (NMs) have been increasingly used in a number of areas, including
consumer products and nanomedicine. Target tissue dosimetry is important in the evaluation …
consumer products and nanomedicine. Target tissue dosimetry is important in the evaluation …
Physiologically based pharmacokinetic (PBPK) modeling of pharmaceutical nanoparticles
M Li, P Zou, K Tyner, S Lee - The AAPS journal, 2017 - Springer
With the great interests in the discovery and development of drug products containing
nanoparticles, there is a great demand of quantitative tools for assessing quality, safety, and …
nanoparticles, there is a great demand of quantitative tools for assessing quality, safety, and …
[HTML][HTML] Nano-and microplastic PBK modeling in the context of human exposure and risk assessment
Insufficient data on nano-and microplastics (NMP) hinder robust evaluation of their potential
health risks. Methodological disparities and the absence of established toxicity thresholds …
health risks. Methodological disparities and the absence of established toxicity thresholds …
Opportunities and challenges of physiologically based pharmacokinetic modeling in drug delivery
W Wang, D Ouyang - Drug Discovery Today, 2022 - Elsevier
Highlights•PBPK modeling bridges drug properties and PK behaviours in drug discovery
and development.•The PBPK is often used in oral formulation development, to address …
and development.•The PBPK is often used in oral formulation development, to address …
Toward a general physiologically-based pharmacokinetic model for intravenously injected nanoparticles
To assess the potential toxicity of nanoparticles (NPs), information concerning their uptake
and disposition (biokinetics) is essential. Experience with industrial chemicals and …
and disposition (biokinetics) is essential. Experience with industrial chemicals and …
Current approaches and techniques in physiologically based pharmacokinetic (PBPK) modelling of nanomaterials
There have been efforts to develop physiologically based pharmacokinetic (PBPK) models
for nanomaterials (NMs). Since NMs have quite different kinetic behaviors, the applicability …
for nanomaterials (NMs). Since NMs have quite different kinetic behaviors, the applicability …
[HTML][HTML] Improving nanotherapy delivery and action through image-guided systems pharmacology
Despite recent advances in the translation of therapeutic nanoparticles (TNPs) into the clinic,
the field continues to face challenges in predictably and selectively delivering nanomaterials …
the field continues to face challenges in predictably and selectively delivering nanomaterials …
Physiologically based pharmacokinetic modeling of nanoparticle biodistribution: a review of existing models, simulation software, and data analysis tools
EO Kutumova, IR Akberdin, IN Kiselev… - International Journal of …, 2022 - mdpi.com
Cancer treatment and pharmaceutical development require targeted treatment and less toxic
therapeutic intervention to achieve real progress against this disease. In this scenario …
therapeutic intervention to achieve real progress against this disease. In this scenario …