The regulation of intracellular calcium (Ca2+) homeostasis is fundamental to maintain
normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular …

Patients with chronic heart failure (HF) have a poor prognosis due to irreversible impairment
of left ventricular function, with 5-year survival rates< 60%. Despite advances in …

Background Polymorphic ventricular tachycardia (PMVT) is a rare genetic disease
associated with structurally normal hearts which in 8% of cases can lead to sudden cardiac …

In the heart, cardiac function is regulated by the autonomic nervous system (ANS) that
extends through the myocardium and establishes junctions at the sinus node and ventricular …

Background Duchenne muscular dystrophy (DMD) is an X‐linked disorder characterized by
progressive muscle weakness due to the absence of functional dystrophin. DMD patients …

Cardiac side effects of some pulmonary drugs are observed in clinical practice.
Aminophylline, a methylxanthine bronchodilator with documented proarrhythmic action, may …

Oxygen, as an external environmental factor, plays a role in the early differentiation of
human stem cells, such as induced pluripotent stem cells (hiPSCs). However, the effect of …

Úvod. Rada běžných plieni ch léčiv může poškozovat kardiovaskulární systém a jejich
dlouhodobé užívání tak může vézt ke vzniku kardiomyopatií, srdečních arytmií, nebo může …