“Ryanopathies” and RyR2 dysfunctions: can we further decipher them using in vitro human disease models?
The regulation of intracellular calcium (Ca2+) homeostasis is fundamental to maintain
normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular …
normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular …
Unlocking the pragmatic potential of regenerative therapies in heart failure with next-generation treatments
Y Kishino, K Fukuda - Biomedicines, 2023 - mdpi.com
Patients with chronic heart failure (HF) have a poor prognosis due to irreversible impairment
of left ventricular function, with 5-year survival rates< 60%. Despite advances in …
of left ventricular function, with 5-year survival rates< 60%. Despite advances in …
Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes
Background Polymorphic ventricular tachycardia (PMVT) is a rare genetic disease
associated with structurally normal hearts which in 8% of cases can lead to sudden cardiac …
associated with structurally normal hearts which in 8% of cases can lead to sudden cardiac …
Impact of neurons on patient-derived cardiomyocytes using organ-on-A-chip and iPSC biotechnologies
AA Bernardin, S Colombani, A Rousselot, V Andry… - Cells, 2022 - mdpi.com
In the heart, cardiac function is regulated by the autonomic nervous system (ANS) that
extends through the myocardium and establishes junctions at the sinus node and ventricular …
extends through the myocardium and establishes junctions at the sinus node and ventricular …
Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy
Background Duchenne muscular dystrophy (DMD) is an X‐linked disorder characterized by
progressive muscle weakness due to the absence of functional dystrophin. DMD patients …
progressive muscle weakness due to the absence of functional dystrophin. DMD patients …
Aminophylline induces two types of arrhythmic events in human pluripotent stem cell–derived cardiomyocytes
S Klimovic, M Scurek, M Pesl, D Beckerova… - Frontiers in …, 2022 - frontiersin.org
Cardiac side effects of some pulmonary drugs are observed in clinical practice.
Aminophylline, a methylxanthine bronchodilator with documented proarrhythmic action, may …
Aminophylline, a methylxanthine bronchodilator with documented proarrhythmic action, may …
Integrating Oxygen and 3D Cell Culture System: A Simple Tool to Elucidate the Cell Fate Decision of hiPSCs
RR Khadim, RK Vadivelu, T Utami, FG Torizal… - International Journal of …, 2022 - mdpi.com
Oxygen, as an external environmental factor, plays a role in the early differentiation of
human stem cells, such as induced pluripotent stem cells (hiPSCs). However, the effect of …
human stem cells, such as induced pluripotent stem cells (hiPSCs). However, the effect of …
[PDF][PDF] VLIV PLICNI MEDIKACE NA FUNKCE KARDIOMYOCYTU
MUDM Ščurek - is.muni.cz
Úvod. Rada běžných plieni ch léčiv může poškozovat kardiovaskulární systém a jejich
dlouhodobé užívání tak může vézt ke vzniku kardiomyopatií, srdečních arytmií, nebo může …
dlouhodobé užívání tak může vézt ke vzniku kardiomyopatií, srdečních arytmií, nebo může …