Detection of cell types contributing to cancer from circulating, cell-free methylated DNA

ME Barefoot, N Loyfer, AJ Kiliti, AP McDeed IV… - Frontiers in …, 2021 - frontiersin.org
Detection of cellular changes in tissue biopsies has been the basis for cancer diagnostics.
However, tissue biopsies are invasive and limited by inaccuracies due to sampling …

Cell-free DNA tissues of origin by methylation profiling reveals significant cell, tissue, and organ-specific injury related to COVID-19 severity

AP Cheng, MP Cheng, W Gu, JS Lenz, E Hsu, E Schurr… - Med, 2021 - cell.com
Summary Background Coronavirus disease 2019 (COVID-19) primarily affects the lungs, but
evidence of systemic disease with multi-organ involvement is emerging. Here, we …

[HTML][HTML] Cell-free DNA in blood reveals significant cell, tissue and organ specific injury and predicts COVID-19 severity

AP Cheng, MP Cheng, W Gu, JS Lenz, E Hsu, E Schurr… - medRxiv, 2020 - ncbi.nlm.nih.gov
COVID-19 primarily affects the lungs, but evidence of systemic disease with multi-organ
involvement is emerging. Here, we developed a blood test to broadly quantify cell, tissue …