Pyrimidine and fused pyrimidine derivatives as promising protein kinase inhibitors for cancer treatment
KRA Abdellatif, RB Bakr - Medicinal Chemistry Research, 2021 - Springer
Pyrimidine ring and its fused derivatives including pyrazolo [3, 4-d] pyrimidine, pyrido [2, 3-d]
pyrimidine, quinazoline, and furo [2, 3-d] pyrimidine compounds had received much interest …
pyrimidine, quinazoline, and furo [2, 3-d] pyrimidine compounds had received much interest …
Biologically Driven Synthesis of Pyrazolo[3,4-d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical …
S Schenone, M Radi, F Musumeci, C Brullo… - Chemical …, 2014 - ACS Publications
1. INTRODUCTION Nitrogen-containing heterocycles are widely distributed in nature and
essential for life, playing a vital role in the metabolism of all living cells. Among the many …
essential for life, playing a vital role in the metabolism of all living cells. Among the many …
Optimized hydrophobic interactions and hydrogen bonding at the target-ligand interface leads the pathways of drug-designing
R Patil, S Das, A Stanley, L Yadav, A Sudhakar… - PloS one, 2010 - journals.plos.org
Background Weak intermolecular interactions such as hydrogen bonding and hydrophobic
interactions are key players in stabilizing energetically-favored ligands, in an open …
interactions are key players in stabilizing energetically-favored ligands, in an open …
A novel pyrimidine derivatives with aryl urea, thiourea and sulfonamide moieties: Synthesis, anti-inflammatory and antimicrobial evaluation
AP Keche, GD Hatnapure, RH Tale, AH Rodge… - Bioorganic & medicinal …, 2012 - Elsevier
A series of novel 4-(3-(trifluoromethyl) phenylamino-6-(4-(3-arylureiodo/arylthioureido/
arylsulfonamido)-pyrimidine derivatives of biological interest were prepared by the …
arylsulfonamido)-pyrimidine derivatives of biological interest were prepared by the …
Molecular iodine promoted synthesis of new pyrazolo [3, 4-d] pyrimidine derivatives as potential antibacterial agents
M Bakavoli, G Bagherzadeh, M Vaseghifar… - European journal of …, 2010 - Elsevier
Molecular iodine promoted synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as potential
antibacterial agents - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals …
antibacterial agents - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals …
[HTML][HTML] Targeting tumor cells with pyrazolo [3, 4-d] pyrimidine scaffold: A literature review on synthetic approaches, structure activity relationship, structural and target …
Abstract Pyrazolo [3, 4-d] pyrimidine had been attracted awesome interest due to its
pharmacological potential especially as an anticancer. Several mechanisms of action were …
pharmacological potential especially as an anticancer. Several mechanisms of action were …
Design, synthesis and antitumor activity of novel pyrazolo [3, 4-d] pyrimidine derivatives as EGFR-TK inhibitors
MA Abdelgawad, RB Bakr, OA Alkhoja… - Bioorganic chemistry, 2016 - Elsevier
Abstract A novel series of 2-(3, 6-dimethyl-1-phenyl-1H-pyrazolo [3, 4-d] pyrimidin-4-yloxy)-
N-(4-substitutedbenzylidene) acetohydrazide (12a–g) was prepared and their structures …
N-(4-substitutedbenzylidene) acetohydrazide (12a–g) was prepared and their structures …
Synthesis and in vitro cytotoxic activity of novel pyrazolo [3, 4-d] pyrimidines and related pyrazole hydrazones toward breast adenocarcinoma MCF-7 cell line
New series of pyrazolo [3, 4-d] pyrimidines (7a–e and 13a–d) and pyrazole hydrazones 17a–
d were synthesized and evaluated for their antiproliferative activity against human breast …
d were synthesized and evaluated for their antiproliferative activity against human breast …
Anti-inflammatory drug approach: Synthesis and biological evaluation of novel pyrazolo [3, 4-d] pyrimidine compounds
In this study, the acid chlorides of pyrazolo [3, 4-d] pyrimidine compounds were prepared
and reacted with a number of nucleophiles. The novel compounds were experimentally …
and reacted with a number of nucleophiles. The novel compounds were experimentally …
Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study
A family of dual Src/Abl inhibitors characterized by a substituted pyrazolo [3, 4-d] pyrimidine
scaffold was previously reported by us and proved to be active against several tumor cell …
scaffold was previously reported by us and proved to be active against several tumor cell …