At present, nine adrenoceptor (AR) subtypes have been identified: α1A-, α1B-, α1D-, α2A-,
α2B-, α2C-, β1-, β2-, and β3AR. In the human heart, β1-and β2AR are the most powerful …

Abstract β-adrenergic receptor (βAR) stimulation by the sympathetic nervous system or
circulating catecholamines is broadly involved in peripheral blood circulation, metabolic …

Background In patients with severe heart failure, prolonged unloading of the myocardium
with the use of a left ventricular assist device has been reported to lead to myocardial …

Background—Intermittent fasting (IF), a dietary regimen in which food is available only every
other day, increases the life span and reduces the incidence of age-associated diseases in …

Background—The upregulation of G protein–coupled receptor kinase 2 in failing
myocardium appears to contribute to dysfunctional β-adrenergic receptor (βAR) signaling …

Objective: To explore the hypothesis that beta-1 adrenoreceptor blockade may be protective
through the attenuation of sympathetic hyperactivity and catecholaminergic inflammatory …

Background—The incidence of heart failure is ever-growing, and it is urgent to develop
improved treatments. An attractive approach is gene therapy; however, the clinical barrier …

Recent studies of adrenoceptors have revealed subtype-specific signaling, promiscuous G-
protein coupling, time-dependent switching of intracellular signaling pathways …

Heart failure (HF) is a major health problem in Western countries. Despite significant
progress in pharmacological and device-based treatment, the disease burden imposed …

Pathologic heart conditions, particularly heart failure (HF) and ischemia-reperfusion (I/R)
injury, are characterized by sustained elevation of plasma and interstitial catecholamine …