Abstract Sirtuins (SIRTs 1− 7), or class III histone deacetylases (HDACs), are protein
deacetylases/ADP ribosyltransferases that target a wide range of cellular proteins in the …

Despite its good initial response and significant survival benefit in patients with castration-
resistant prostate cancer (CRPC), taxane therapy inevitably encounters drug resistance in …

Although systemic androgen deprivation prolongs life in advanced prostate cancer,
remissions are temporary because patients almost uniformly progress to a state of a …

Background Prostate-specific membrane antigen (PSMA) is a promising target for
diagnostics and therapy of prostate carcinoma (PCa). Based on the hypothesis that PSMA …

Despite advances in detection and therapy, castration-resistant prostate cancer continues to
be a major clinical problem. The aberrant activity of stem cell pathways, and their regulation …

Castration-resistant prostate cancer continues to rely on androgen receptor (AR) expression.
AR plays a central role in the development of prostate cancer and progression to castration …

Residual tissue androgens are consistently detected within the prostate tumors of castrate
individuals and are thought to play a critical role in facilitating the androgen receptor …

PURPOSE: Androgens are essential for prostatic growth and development but they also
have a significant role in prostate disease pathogenesis. Dihydrotestosterone, the primary …

The androgen receptor (AR) and the androgen–AR signaling pathway play a significant role
in male sexual differentiation and the development and function of male reproductive and …

Prostate cancer is the most frequently diagnosed non‐skin cancer and the third leading
cause of cancer mortality in men. In the initial stages, prostate cancer is dependent on …