Fundamental importance of ionic interactions in the liquid phase: A review of recent studies of ionic liquids in biomedical and pharmaceutical applications
KS Egorova, VP Ananikov - Journal of Molecular Liquids, 2018 - Elsevier
In recent years, research on ions and ionic interactions in solution has become a leading
scientific direction, and this advance has been especially pronounced in the field of ionic …
scientific direction, and this advance has been especially pronounced in the field of ionic …
[HTML][HTML] Alternative excipients for protein stabilization in protein therapeutics: overcoming the limitations of polysorbates
AJ Castañeda Ruiz, MA Shetab Boushehri, T Phan… - Pharmaceutics, 2022 - mdpi.com
Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been
the most widely used excipients for the stabilization of protein therapeutics for years. In …
the most widely used excipients for the stabilization of protein therapeutics for years. In …
Contemporary advancement of cholinium-based ionic liquids for protein stability and long-term storage: Past, present, and future outlook
In the past two decades, ionic liquids (ILs) have been acknowledged as potentially attractive
“green” and “designer” solvents since their broader chemical space and the tunable nature …
“green” and “designer” solvents since their broader chemical space and the tunable nature …
Ionic liquids as biocompatible stabilizers of proteins
Ionic liquids (ILs) have recently emerged as versatile solvents and additives in the field of
biotechnology, particularly as stabilizers of proteins and enzymes. Of interest to the …
biotechnology, particularly as stabilizers of proteins and enzymes. Of interest to the …
Binding study of antibacterial drug ciprofloxacin with imidazolium-based ionic liquids having different halide anions: A spectroscopic and density functional theory …
Herein, we have shown the interaction of an antibiotic drug ciprofloxacin (CIP) with three
surface-active ionic liquids (ILs), having the same cation and different anions, namely, 1 …
surface-active ionic liquids (ILs), having the same cation and different anions, namely, 1 …
Enhanced performance of polymer-polymer aqueous two-phase systems using ionic liquids as adjuvants towards the purification of recombinant proteins
Protein biopharmaceuticals, among which interferon alpha-2b (IFNα-2b) that can be used in
the treatment of chronic hepatitis C and hairy cell leukemia, have become an indispensable …
the treatment of chronic hepatitis C and hairy cell leukemia, have become an indispensable …
Correlating Bromelain's activity with its structure and active-site dynamics and the medium's physical properties in a hydrated deep eutectic solvent
Deep eutectic solvents (DESs) are emerging as new media of choice for biocatalysis due to
their environmentally friendly nature, fine-tunability, and potential biocompatibility. This work …
their environmentally friendly nature, fine-tunability, and potential biocompatibility. This work …
Potential application of ionic liquids in pharmaceutical dosage forms for small molecule drug and vaccine delivery system
MN Uddin, D Basak, R Hopefl… - Journal of Pharmacy & …, 2020 - journals.library.ualberta.ca
Ionic liquids are salts in which the ions are poorly coordinated, which causes them to exist in
liquid form below 100 C, or at room temperature. Therefore, these are also defined as room …
liquid form below 100 C, or at room temperature. Therefore, these are also defined as room …
Ionic liquids: promising approach for oral drug delivery
L Jiang, Y Sun, A Lu, X Wang, Y Shi - Pharmaceutical Research, 2022 - Springer
Oral administration is the most preferred route for drug administration in clinic. However, due
to unsatisfactory physicochemical properties of drugs and various physiological barriers, the …
to unsatisfactory physicochemical properties of drugs and various physiological barriers, the …
Strategic planning of proteins in ionic liquids: future solvents for the enhanced stability of proteins against multiple stresses
Ionic liquids (ILs) present a vast number of solvents capable of replacing toxic organic
solvents in chemical, biotechnology and biomedical applications. ILs are inexpensive and …
solvents in chemical, biotechnology and biomedical applications. ILs are inexpensive and …