[HTML][HTML] Lung parenchymal mechanics
The lung parenchyma comprises a large number of thin-walled alveoli, forming an
enormous surface area, which serves to maintain proper gas exchange. The alveoli are held …
enormous surface area, which serves to maintain proper gas exchange. The alveoli are held …
Quantitative microscopy of the lung: a problem-based approach. Part 2: stereological parameters and study designs in various diseases of the respiratory tract
C Mühlfeld, M Ochs - … journal of physiology-lung cellular and …, 2013 - journals.physiology.org
Design-based stereology provides efficient methods to obtain valuable quantitative
information of the respiratory tract in various diseases. However, the choice of the most …
information of the respiratory tract in various diseases. However, the choice of the most …
Epithelial Vegfa specifies a distinct endothelial population in the mouse lung
LV Ellis, MP Cain, V Hutchison, P Flodby, ED Crandall… - Developmental cell, 2020 - cell.com
The lung microvasculature is essential for gas exchange and commonly considered
homogeneous. We show that VEGFA from the epithelium is required for a distinct …
homogeneous. We show that VEGFA from the epithelium is required for a distinct …
Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis
S Ortiz-Espinosa, X Morales, Y Senent, D Alignani… - Cancer letters, 2022 - Elsevier
Myeloid-derived suppressor cells (MDSCs) play a major role in cancer progression. In this
study, we investigated the mechanisms by which complement C5a increases the capacity of …
study, we investigated the mechanisms by which complement C5a increases the capacity of …
Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice
SM Cloonan, K Glass, ME Laucho-Contreras… - Nature medicine, 2016 - nature.com
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and
genetic determinants. We have previously identified iron-responsive element–binding …
genetic determinants. We have previously identified iron-responsive element–binding …
Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema
ZH Chen, HC Lam, Y Jin, HP Kim… - Proceedings of the …, 2010 - National Acad Sciences
Chronic obstructive pulmonary disease (COPD) is a debilitating disease caused by chronic
exposure to cigarette smoke (CS), which involves airway obstruction and alveolar loss (ie …
exposure to cigarette smoke (CS), which involves airway obstruction and alveolar loss (ie …
Quantitative lung morphology: semi-automated measurement of mean linear intercept
Background Quantifying morphologic changes is critical to our understanding of the
pathophysiology of the lung. Mean linear intercept (MLI) measures are important in the …
pathophysiology of the lung. Mean linear intercept (MLI) measures are important in the …
Assessment of air space size characteristics by intercept (chord) measurement: an accurate and efficient stereological approach
The mean linear intercept (chord) length (L m) is a useful parameter of peripheral lung
structure as it describes the mean free distance in the air spaces. It is often misinterpreted as …
structure as it describes the mean free distance in the air spaces. It is often misinterpreted as …
Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation
Deficiency of vitamin D is associated with accelerated decline in lung function. Vitamin D is a
ligand for nuclear hormone vitamin D receptor (VDR), and upon binding it modulates various …
ligand for nuclear hormone vitamin D receptor (VDR), and upon binding it modulates various …
Gallic acid suppresses inflammation and oxidative stress through modulating Nrf2-HO-1-NF-κB signaling pathways in elastase-induced emphysema in rats
Emphysema is associated with an abnormal airspace enlargement distal to the terminal
bronchioles accompanied by destructive changes in the alveolar walls and chronic …
bronchioles accompanied by destructive changes in the alveolar walls and chronic …