The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in
nature for millions of years. The human infection, named Chagas disease, is a major public …

Over the last 30 years, concomitant with successful transnational disease control programs
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …

Genetic variation in Trypanosoma cruzi is likely a key determinant in transmission and
pathogenesis of Chagas disease. We have examined nine loci as markers for the extant T …

Infection with the protozoan parasite Trypanosoma cruzi, the agent of Chagas disease, is
characterised by a variable clinical course–from symptomless cases to severe chronic …

Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately
one-third of individuals infected with the protozoan parasite Trypanosoma cruzi. Since the …

Chagas disease is an important vector-borne neglected tropical disease that causes great
health and economic losses. The etiological agent, Trypanosoma cruzi, is a protozoan …

Relatively little is known about the fitness effects and life history trade-offs in medically
important parasites and their insect vectors. One such case is the triatomine bugs and the …

The genetic palette from which the spectrum of variability in Trypanosoma cruzi has been
drawn is astonishingly limited. In this review we address the roots of this unusual pedigree …

Whereas mammalian cells and most other organisms can synthesize polyamines from basic
amino acids, the protozoan parasite Trypanosoma cruzi is incapable of polyamine …

Trypanosoma cruzi, responsible for Chagas disease, is a serious public health problem in
Latin America with eight million people infected in the world. Clinical manifestations …