Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …

Highlights•The intrinsic dynamics, encoded in proteins' sequences and structures, are
utilized by stimuli to trigger allosteric and functional actions.•The modes of allosteric actions …

Highlights•Allosteric drugs have become an indispensable tool in precision medicine.•Major
targets for allosteric drugs: diversity structures and functions.•Allosteric effects of mutations …

Abstract NAD (P) H quinone oxidoreductase 1 (NQO1) is a multi-functional protein that
catalyses the reduction of quinones (and other molecules), thus playing roles in xenobiotic …

Regardless of the diversity of systems, allosteic signalling is found to be always caused by
perturbations. This recurring trait of allostery serves as a foundation for developing different …

The interactions between residues in a protein tertiary structure can be studied effectively
using the approach of protein structure network (PSN). A PSN is a node-edge representation …

Apoptosis is an essential defensive mechanism against tumorigenesis. Proteins of the B-cell
lymphoma-2 (Bcl-2) family regulate programmed cell death by the mitochondrial apoptosis …

Heterozygous, missense mutations in both α-and β-tubulin genes have been linked to an
array of neurodevelopment disorders, commonly referred to as “tubulinopathies.” To date …

Temperature-dependent evolution of enzymes allowed for biological adaptation to the wide
range of temperatures found across Earth's ecological niches. Adaptation of enzyme activity …

G-protein-coupled receptors (GPCRs) are ubiquitous integral membrane proteins involved
in diverse cellular signaling processes. Here, we carry out a large-scale ensemble …