Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular
membranes, and regulate energy metabolism. Questions remain as to which lipid species …

Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …

Aims Sodium-glucose co-transporter 2 (SGLT2) inhibitors improve cardiovascular outcomes
in diverse patient populations, but their mechanism of action requires further study. The aim …

Understanding nephron loss is a primary strategy for preventing CKD progression. Death of
renal tubular cells may occur by apoptosis during developmental and regenerative …

Acute kidney injury (AKI) exhibits high morbidity and mortality. Kidney injury molecule-1
(KIM1) is dramatically upregulated in renal tubules upon injury, and acts as a biomarker for …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected conditions,
and CKD is projected to become the fifth leading global cause of death by 2040. New …

The prevalence of obesity has increased dramatically during the past decades, which has
been a major health problem. Since 1975, the number of people with obesity worldwide has …

Metabolic reprogramming to glycolysis is closely associated with the development of chronic
kidney disease (CKD). Although it has been reported that phosphofructokinase 1 (PFK) is a …

Tubular injury has been shown to play a critical role in the morbidity of diabetic kidney
disease (DKD); ferroptosis often occurs in tubules during renal disease development. This …

SARS-CoV-2 precipitates respiratory distress by infection of airway epithelial cells and is
often accompanied by acute kidney injury. We report that Kidney Injury Molecule-1/T cell …