The drug nanocrystals (NCs) with unique physicochemical properties are now considered
as a promising drug delivery system for poorly water-soluble drugs. So far> 20 formulations …

With the limitation of solubility and dissolution rate of insoluble drugs, following oral
administration, they would rifely prove poor and volatile bioavailability, which may fail to …

Human cytomegalovirus (CMV) retinitis is a sight-threatening inflammation of the retina
commonly affected immunocompromised patients, eg, acquired immunodeficiency …

Abstract “Brick dust” compounds have high lattice energy as manifested by the poor
aqueous solubility and suboptimal bioavailability. Nilotinib being a weakly basic brick dust …

Nanosuspensions have received much attention in enhanced transdermal delivery.
However, the corresponding mechanisms have not been clarified. In particular, whether …

Little is known about the in vivo fate of drug particles taken orally, in particular, the drug
release kinetics and interaction with the gastrointestinal (GI) membrane. Lacking is …

Nanocrystals are of great value in delivering poorly soluble drugs as a technique enables
enhanced dissolution and bioavailability. The bottom-up technique allows better control of …

Meloxicam (MLX) is efficient in relieving pain and inflammatory symptoms, which, however,
is limited by the poor solubility and gastrointestinal side effects. The objective of this study is …

Hearing loss is a widespread condition, affecting people from a range of demographics.
Gene therapy is an emerging method for the amelioration of this condition. Challenges …

The objective of this work was to prepare and evaluate fast dissolving sublingual films
containing meloxicam nanocrystals (MLX-NS-FDSFs). Nanocrystals (NS) were utilized to …