Angiogenesis is a significant event in a wide range of healthy and diseased conditions. This
process frequently involves vasodilation and an increase in vascular permeability …

Context Adjuvant chemotherapy (AC) improves survival among patients with resected
colorectal cancer. However, the optimal timing from surgery to initiation of AC is unknown …

Recent discoveries of endogenous negative regulators of angiogenesis, thrombospondin,
angiostatin and glioma-derived angiogenesis inhibitory factor, all associated with …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

New blood vessel formation (angiogenesis) is a fundamental event in the process of tumor
growth and metastatic dissemination. Hence, the molecular basis of tumor angiogenesis has …

In cancer metastasis, only a small percentage of cells released from a primary tumor
successfully form distant lesions, but it is uncertain at which steps in the process cells are …

IL-8, a member of the chemokine family, has been shown to play an important role in tumor
growth, angiogenesis, and metastasis. The objective of this study was to determine the …

Background Microcell-mediated transfer of chromosome 6 into human C8161 and MelJuSo
melanoma cells suppresses their ability to metastasize by at least 95% without affecting their …

In cancer patients, dormant micrometastases are often asymptomatic and clinically
undetectable, for months or years, until relapse. We have studied dormant lung metastases …

Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator composed of HIF-1α and HIF-
1β subunits. Several dozen HIF-1 targets are known, including the gene encoding vascular …