Repositioning TH cell polarization from single cytokines to complex help
S Tuzlak, AS Dejean, M Iannacone, FJ Quintana… - Nature …, 2021 - nature.com
When helper T (TH) cell polarization was initially described three decades ago, the TH cell
universe grew dramatically. New subsets were described based on their expression of few …
universe grew dramatically. New subsets were described based on their expression of few …
Interferon pathway in SLE: one key to unlocking the mystery of the disease
L Rönnblom, D Leonard - Lupus science & medicine, 2019 - lupus.bmj.com
SLE is characterised by an activation of the interferon (IFN) system, which leads to an
increased expression of IFN-regulated genes. The reasons behind the IFN signature in SLE …
increased expression of IFN-regulated genes. The reasons behind the IFN signature in SLE …
Antitumour actions of interferons: implications for cancer therapy
BS Parker, J Rautela, PJ Hertzog - Nature Reviews Cancer, 2016 - nature.com
The interferons (IFNs) are a family of cytokines that protect against disease by direct effects
on target cells and by activating immune responses. The production and actions of IFNs are …
on target cells and by activating immune responses. The production and actions of IFNs are …
Interferome v2. 0: an updated database of annotated interferon-regulated genes
I Rusinova, S Forster, S Yu, A Kannan… - Nucleic acids …, 2012 - academic.oup.com
Abstract Interferome v2. 0 (http://interferome. its. monash. edu. au/interferome/) is an update
of an earlier version of the Interferome DB published in the 2009 NAR database edition …
of an earlier version of the Interferome DB published in the 2009 NAR database edition …
Interferon-inducible effector mechanisms in cell-autonomous immunity
JD MacMicking - Nature Reviews Immunology, 2012 - nature.com
Interferons (IFNs) induce the expression of hundreds of genes as part of an elaborate
antimicrobial programme designed to combat infection in all nucleated cells—a process …
antimicrobial programme designed to combat infection in all nucleated cells—a process …
High levels of circulating interferons type I, type II and type III associate with distinct clinical features of active systemic lupus erythematosus
V Oke, I Gunnarsson, J Dorschner, S Eketjäll… - Arthritis research & …, 2019 - Springer
Abstract Background and aim Interferons (IFNs) are considered to be key molecules in the
pathogenesis of systemic lupus erythematosus (SLE). We measured levels of type I, II and III …
pathogenesis of systemic lupus erythematosus (SLE). We measured levels of type I, II and III …
Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus
N Buang, L Tapeng, V Gray, A Sardini… - Nature …, 2021 - nature.com
The majority of patients with systemic lupus erythematosus (SLE) have high expression of
type I IFN-stimulated genes. Mitochondrial abnormalities have also been reported, but the …
type I IFN-stimulated genes. Mitochondrial abnormalities have also been reported, but the …
Type I and II interferon signatures in Sjogren's syndrome pathogenesis: contributions in distinct clinical phenotypes and Sjogren's related lymphomagenesis
A Nezos, F Gravani, A Tassidou… - Journal of …, 2015 - Elsevier
Both type I and II interferons (IFNs) have been implicated in the pathogenesis of Sjogren's
syndrome (SS). We aimed to explore the contribution of type I and II IFN signatures in the …
syndrome (SS). We aimed to explore the contribution of type I and II IFN signatures in the …
[HTML][HTML] Interferon-γ and systemic autoimmunity
KM Pollard, DM Cauvi, CB Toomey, KV Morris… - Discovery …, 2013 - ncbi.nlm.nih.gov
The term interferon describes a family of proteins consisting of three major types (I, II, III)
which differ in their primary protein sequences, cognate receptors, genetic loci, and cell …
which differ in their primary protein sequences, cognate receptors, genetic loci, and cell …
The interferon signature in autoimmune diseases
L Rönnblom, ML Eloranta - Current opinion in rheumatology, 2013 - journals.lww.com
The interferon signature in autoimmune diseases : Current Opinion in Rheumatology The
interferon signature in autoimmune diseases : Current Opinion in Rheumatology Log in or …
interferon signature in autoimmune diseases : Current Opinion in Rheumatology Log in or …