A review of dietary (phyto) nutrients for glutathione support

DM Minich, BI Brown - Nutrients, 2019 - mdpi.com
Glutathione is a tripeptide that plays a pivotal role in critical physiological processes
resulting in effects relevant to diverse disease pathophysiology such as maintenance of …

An update on pharmacotherapy of autism spectrum disorder in children and adolescents

R Goel, JS Hong, RL Findling, NY Ji - International review of …, 2018 - Taylor & Francis
To date, no medication is proven to be effective in treating core symptoms of autism
spectrum disorder (ASD). Psychotropic medications are widely used to target emotional and …

The role of glutathione redox imbalance in autism spectrum disorder: a review

G Bjørklund, AA Tinkov, B Hosnedlová, R Kizek… - Free Radical Biology …, 2020 - Elsevier
The role of glutathione in autism spectrum disorder (ASD) is emerging as a major topic, due
to its role in the maintenance of the intracellular redox balance. Several studies have …

Social skills deficits in autism spectrum disorder: potential biological origins and progress in developing therapeutic agents

RE Frye - CNS drugs, 2018 - Springer
Autism spectrum disorder is defined by two core symptoms: a deficit in social communication
and the presence of repetitive behaviors and/or restricted interests. Currently, there is no US …

Glutathione in brain: overview of its conformations, functions, biochemical characteristics, quantitation and potential therapeutic role in brain disorders

D Dwivedi, K Megha, R Mishra, PK Mandal - Neurochemical research, 2020 - Springer
Glutathione (GSH) is an important antioxidant found abundantly and synthesized
intracellularly in the cytosol in a tightly regulated fashion. It has diverse physiological …

Mitochondria, metabolism, and redox mechanisms in psychiatric disorders

Y Kim, KC Vadodaria, Z Lenkei, T Kato… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

The Potential of N-Acetyl-L-Cysteine (NAC) in the Treatment of Psychiatric Disorders

RCJ Bradlow, M Berk, PW Kalivas, SE Back… - CNS drugs, 2022 - Springer
Abstract N-acetyl-L-cysteine (NAC) is a compound of increasing interest in the treatment of
psychiatric disorders. Primarily through its antioxidant, anti-inflammatory, and glutamate …

Repeated‐dose oral N‐acetylcysteine in Parkinson's disease: pharmacokinetics and effect on brain glutathione and oxidative stress

LD Coles, PJ Tuite, G Öz, UR Mishra… - The Journal of …, 2018 - Wiley Online Library
Parkinson's disease (PD) is associated with oxidative stress and decreased nigral
glutathione (GSH), suggesting that therapies that boost GSH may have a disease‐modifying …

The parvalbumin hypothesis of autism spectrum disorder

F Filice, L Janickova, T Henzi, A Bilella… - Frontiers in Cellular …, 2020 - frontiersin.org
The prevalence of autism spectrum disorder (ASD)—a type of neurodevelopmental disorder—
is increasing and is around 2% in North America, Asia, and Europe. Besides the known …

Meta-analysis: pharmacologic treatment of restricted and repetitive behaviors in autism spectrum disorders

MS Zhou, M Nasir, LC Farhat, M Kook… - Journal of the American …, 2021 - Elsevier
Objective To examine the efficacy of pharmacological treatments for restricted and repetitive
behaviors (RRB) in autism spectrum disorders (ASD). Method We searched PubMed …