[HTML][HTML] Detection and analysis of chiral molecules as disease biomarkers

Y Liu, Z Wu, DW Armstrong, H Wolosker… - Nature Reviews …, 2023 - nature.com
The chirality of small metabolic molecules is important in controlling physiological processes
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …

Quality assurance procedures for mass spectrometry untargeted metabolomics. a review

D Dudzik, C Barbas-Bernardos, A García… - … of pharmaceutical and …, 2018 - Elsevier
Untargeted metabolomics, as a global approach, has already proven its great potential and
capabilities for the investigation of health and disease, as well as the wide applicability for …

Ms-based lipidomics of human blood plasma: A community-initiated position paper to develop accepted guidelines1

B Burla, M Arita, M Arita, AK Bendt… - Journal of lipid …, 2018 - ASBMB
Human blood is a self-regenerating lipid-rich biological fluid that is routinely collected in
hospital settings. The inventory of lipid molecules found in blood plasma (plasma lipidome) …

Nutrimetabolomics: an integrative action for metabolomic analyses in human nutritional studies

MM Ulaszewska, CH Weinert… - Molecular nutrition & …, 2019 - Wiley Online Library
The life sciences are currently being transformed by an unprecedented wave of
developments in molecular analysis, which include important advances in instrumental …

[HTML][HTML] Metabolomics for clinical use and research in chronic kidney disease

B Hocher, J Adamski - Nature Reviews Nephrology, 2017 - nature.com
Chronic kidney disease (CKD) has a high prevalence in the general population and is
associated with high mortality; a need therefore exists for better biomarkers for diagnosis …

[HTML][HTML] Promises and pitfalls of untargeted metabolomics

I Gertsman, BA Barshop - Journal of inherited metabolic disease, 2018 - Springer
Metabolomics is one of the newer omics fields, and has enabled researchers to complement
genomic and protein level analysis of disease with both semi-quantitative and quantitative …

Mass spectrometry-based plasma proteomics: considerations from sample collection to achieving translational data

V Ignjatovic, PE Geyer, KK Palaniappan… - Journal of proteome …, 2019 - ACS Publications
The proteomic analysis of human blood and blood-derived products (eg, plasma) offers an
attractive avenue to translate research progress from the laboratory into the clinic. However …

Sample normalization methods in quantitative metabolomics

Y Wu, L Li - Journal of Chromatography A, 2016 - Elsevier
To reveal metabolomic changes caused by a biological event in quantitative metabolomics,
it is critical to use an analytical tool that can perform accurate and precise quantification to …

Cancer metabolites: promising biomarkers for cancer liquid biopsy

W Wang, Z Rong, G Wang, Y Hou, F Yang, M Qiu - Biomarker Research, 2023 - Springer
Cancer exerts a multitude of effects on metabolism, including the reprogramming of cellular
metabolic pathways and alterations in metabolites that facilitate inappropriate proliferation of …

Pre-analytical factors that affect metabolite stability in human urine, plasma, and serum: a review

VL Stevens, E Hoover, Y Wang, KA Zanetti - Metabolites, 2019 - mdpi.com
Metabolomics provides a comprehensive assessment of numerous small molecules in
biological samples. As it integrates the effects of exogenous exposures, endogenous …