Covalent drugs have been used to treat diseases for more than a century, but tools that
facilitate the rational design of covalent drugs have emerged more recently. The purposeful …

Covalent inhibitors and other types of covalent modalities have seen a revival in the past two
decades, with a variety of new targeted covalent drugs having been approved in recent …

Activity-based protein profiling (ABPP) is a versatile strategy for identifying and
characterizing functional protein sites and compounds for therapeutic development …

Electrophilic cofactors are widely distributed in nature and play important roles in many
physiological and disease processes, yet they have remained blind spots in traditional …

Stress induced amorphous proteome aggregation is a hallmark for diseased cells, with the
proteomic composition intimately associated with disease pathogenicity. Due to its …

Cysteine chemoproteomic screening platforms are widely utilized for chemical probe and
drug discovery campaigns. Chemoproteomic compound screens, which use a mass …

Cell membrane glycoproteins are generally highly fucosylated and sialylated, and post-
translational modifications play important roles in the proteins' functions of signaling, binding …

Chemical proteomics utilizes small-molecule probes to covalently engage with their
interacting proteins. Since chemical probes are tagged to the active or binding sites of …

Over the past two decades, activity-based probes have enabled a range of discoveries,
including the characterization of new enzymes and drug targets. However, their suitability in …

Redox signaling is a fundamental mechanism that controls all major biological processes
partly via protein cysteine oxidations, including S-glutathionylation. Despite over 2000 …